TY  - JOUR
AU  - Höglinger, G. U.
AU  - Respondek, G.
AU  - Kovacs, G. G.
TI  - New classification of tauopathies.
JO  - Revue neurologique
VL  - 174
IS  - 9
SN  - 0035-3787
CY  - Issy-les-Moulineaux
PB  - Elsevier Masson
M1  - DZNE-2020-06606
SP  - 664-668
PY  - 2018
AB  - Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.
KW  - Humans
KW  - Neurodegenerative Diseases: classification
KW  - Neurodegenerative Diseases: genetics
KW  - Supranuclear Palsy, Progressive: classification
KW  - Supranuclear Palsy, Progressive: genetics
KW  - Supranuclear Palsy, Progressive: physiopathology
KW  - Tauopathies: classification
KW  - Tauopathies: genetics
KW  - Tauopathies: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:30098799
DO  - DOI:10.1016/j.neurol.2018.07.001
UR  - https://pub.dzne.de/record/140284
ER  -