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000140301 0247_ $$2ISSN$$a1081-0706
000140301 0247_ $$2ISSN$$a1530-8995
000140301 0247_ $$2ISSN$$a2331-1045
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000140301 037__ $$aDZNE-2020-06623
000140301 041__ $$aEnglish
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000140301 1001_ $$0P:(DE-2719)2811540$$aCurcio, Michele$$b0$$eFirst author$$udzne
000140301 245__ $$aAxon Regeneration in the Central Nervous System: Facing the Challenges from the Inside.
000140301 260__ $$aPalo Alto, Calif.$$bAnnual Reviews$$c2018
000140301 264_1 $$2Crossref$$3print$$bAnnual Reviews$$c2018-10-06
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000140301 520__ $$aAfter an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications-control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.
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000140301 650_2 $$2MeSH$$aAnimals
000140301 650_2 $$2MeSH$$aAxonal Transport: genetics
000140301 650_2 $$2MeSH$$aAxons: metabolism
000140301 650_2 $$2MeSH$$aAxons: physiology
000140301 650_2 $$2MeSH$$aCentral Nervous System: growth & development
000140301 650_2 $$2MeSH$$aHumans
000140301 650_2 $$2MeSH$$aMammals
000140301 650_2 $$2MeSH$$aNerve Regeneration: genetics
000140301 650_2 $$2MeSH$$aPeripheral Nervous System: growth & development
000140301 7001_ $$0P:(DE-2719)2810270$$aBradke, Frank$$b1$$eLast author$$udzne
000140301 77318 $$2Crossref$$3journal-article$$a10.1146/annurev-cellbio-100617-062508$$b : Annual Reviews, 2018-10-06$$n1$$p495-521$$tAnnual Review of Cell and Developmental Biology$$v34$$x1081-0706$$y2018
000140301 773__ $$0PERI:(DE-600)1470447-X$$a10.1146/annurev-cellbio-100617-062508$$gVol. 34, no. 1, p. 495 - 521$$n1$$p495-521$$q34:1<495 - 521$$tAnnual review of cell and developmental biology$$v34$$x1081-0706$$y2018
000140301 8564_ $$uhttps://www.annualreviews.org/doi/10.1146/annurev-cellbio-100617-062508
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