Journal Article (Review Article)

DZNE-2020-06623

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside.

Curcio, M. (First author)DZNE* ; Bradke, F. (Last author)DZNE*

2018
Annual Reviews Palo Alto, Calif.

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Please use a persistent id in citations: doi:10.1146/annurev-cellbio-100617-062508

Abstract: After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications-control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.

Keyword(s): Animals (MeSH) ; Axonal Transport: genetics (MeSH) ; Axons: metabolism (MeSH) ; Axons: physiology (MeSH) ; Central Nervous System: growth & development (MeSH) ; Humans (MeSH) ; Mammals (MeSH) ; Nerve Regeneration: genetics (MeSH) ; Peripheral Nervous System: growth & development (MeSH)

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Contributing Institute(s):

1. Axon Growth and Regeneration (AG Bradke)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2018

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Database coverage:
; Allianz-Lizenz / DFG ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; IF >= 10 ; JCR ; SCOPUS ; Web of Science Core Collection

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