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@ARTICLE{Curcio:140301,
      author       = {Curcio, Michele and Bradke, Frank},
      title        = {{A}xon {R}egeneration in the {C}entral {N}ervous {S}ystem:
                      {F}acing the {C}hallenges from the {I}nside.},
      journal      = {Annual review of cell and developmental biology},
      volume       = {34},
      number       = {1},
      issn         = {1081-0706},
      address      = {Palo Alto, Calif.},
      publisher    = {Annual Reviews},
      reportid     = {DZNE-2020-06623},
      pages        = {495-521},
      year         = {2018},
      abstract     = {After an injury in the adult mammalian central nervous
                      system (CNS), lesioned axons fail to regenerate. This
                      failure to regenerate contrasts with axons' remarkable
                      potential to grow during embryonic development and after an
                      injury in the peripheral nervous system (PNS). Several
                      intracellular mechanisms-including cytoskeletal dynamics,
                      axonal transport and trafficking, signaling and
                      transcription of regenerative programs, and epigenetic
                      modifications-control axon regeneration. In this review, we
                      describe how manipulation of intrinsic mechanisms elicits a
                      regenerative response in different organisms and how
                      strategies are implemented to form the basis of a future
                      regenerative treatment after CNS injury.},
      subtyp        = {Review Article},
      keywords     = {Animals / Axonal Transport: genetics / Axons: metabolism /
                      Axons: physiology / Central Nervous System: growth $\&$
                      development / Humans / Mammals / Nerve Regeneration:
                      genetics / Peripheral Nervous System: growth $\&$
                      development},
      cin          = {AG Bradke},
      ddc          = {570},
      cid          = {I:(DE-2719)1013002},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30044649},
      doi          = {10.1146/annurev-cellbio-100617-062508},
      url          = {https://pub.dzne.de/record/140301},
}