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024 7 _ |a 10.1146/annurev-cellbio-100617-062508
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024 7 _ |a 0743-4634
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024 7 _ |a 1081-0706
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024 7 _ |a 1530-8995
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024 7 _ |a 2331-1045
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037 _ _ |a DZNE-2020-06623
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Curcio, Michele
|0 P:(DE-2719)2811540
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245 _ _ |a Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside.
260 _ _ |a Palo Alto, Calif.
|c 2018
|b Annual Reviews
264 _ 1 |3 print
|2 Crossref
|b Annual Reviews
|c 2018-10-06
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications-control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Axonal Transport: genetics
|2 MeSH
650 _ 2 |a Axons: metabolism
|2 MeSH
650 _ 2 |a Axons: physiology
|2 MeSH
650 _ 2 |a Central Nervous System: growth & development
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mammals
|2 MeSH
650 _ 2 |a Nerve Regeneration: genetics
|2 MeSH
650 _ 2 |a Peripheral Nervous System: growth & development
|2 MeSH
700 1 _ |a Bradke, Frank
|0 P:(DE-2719)2810270
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|e Last author
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773 1 8 |a 10.1146/annurev-cellbio-100617-062508
|b : Annual Reviews, 2018-10-06
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|p 495-521
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|t Annual Review of Cell and Developmental Biology
|v 34
|y 2018
|x 1081-0706
773 _ _ |a 10.1146/annurev-cellbio-100617-062508
|g Vol. 34, no. 1, p. 495 - 521
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|t Annual review of cell and developmental biology
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856 4 _ |u https://www.annualreviews.org/doi/10.1146/annurev-cellbio-100617-062508
909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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