Journal Article (Review Article)

DZNE-2020-06815

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation.

Schultze, J. (First author)DZNE* ; Mass, E. ; Schlitzer, A.

2019
Elsevier New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.immuni.2019.01.019

Abstract: Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological advances in fate mapping and genetic engineering, as well as the advent of single cell RNA-sequencing, have highlighted the heterogeneity of the hematopoietic system and revealed new concepts in myeloid cell ontogeny. These technologies are also shedding light on mechanisms of myelopoiesis at homeostasis and at different phases of infection and inflammation, illustrating important feedback loops between affected tissues and the bone marrow. We review these findings here and revisit principles in myelopoiesis in light of the evolving understanding of myeloid cell ontogeny and heterogeneity. We argue for the importance of system-wide evaluation of changes in myelopoiesis and discuss how even after the resolution of inflammation, long-lasting alterations in myelopoiesis may play a role in innate immune memory or trained immunity.

Keyword(s): Animals (MeSH) ; Bone Marrow: immunology (MeSH) ; Homeostasis: immunology (MeSH) ; Humans (MeSH) ; Immunity, Innate: immunology (MeSH) ; Infections: immunology (MeSH) ; Inflammation: immunology (MeSH) ; Models, Immunological (MeSH) ; Myeloid Cells: immunology (MeSH) ; Myeloid Progenitor Cells: immunology (MeSH) ; Myelopoiesis: immunology (MeSH)

---

Contributing Institute(s):

1. Platform for Single Cell Genomics and Epigenomics (Schultze - PRECISE)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

---

Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 40 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

---