%0 Journal Article
%A Haass, Christian
%A Willem, Michael
%T Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?
%J Neuron
%V 101
%N 4
%@ 0896-6273
%C New York, NY
%I Elsevier
%M DZNE-2020-06817
%P 557-559
%D 2019
%X The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.
%K Amyloid beta-Peptides
%K Amyloid beta-Protein Precursor
%K Biological Transport
%K Ligands
%K Synaptic Transmission
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30790537
%R 10.1016/j.neuron.2019.01.058
%U https://pub.dzne.de/record/140495