Journal Article (Editorial)

DZNE-2020-06817

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Haass, C. (First author)DZNE* ; Willem, M. (Last author)DZNE*

2019
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2019.01.058

Abstract: The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.

Keyword(s): Amyloid beta-Peptides (MeSH) ; Amyloid beta-Protein Precursor (MeSH) ; Biological Transport (MeSH) ; Ligands (MeSH) ; Synaptic Transmission (MeSH)

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Contributing Institute(s):

1. ALS, FTLD and Zebrafish models (AG Haass old)
2. Ext Ludwig-Maximilians-University (Ext LMU)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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