TY  - JOUR
AU  - Haass, Christian
AU  - Willem, Michael
TI  - Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?
JO  - Neuron
VL  - 101
IS  - 4
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2020-06817
SP  - 557-559
PY  - 2019
AB  - The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.
KW  - Amyloid beta-Peptides
KW  - Amyloid beta-Protein Precursor
KW  - Biological Transport
KW  - Ligands
KW  - Synaptic Transmission
LB  - PUB:(DE-HGF)16
C6  - pmid:30790537
DO  - DOI:10.1016/j.neuron.2019.01.058
UR  - https://pub.dzne.de/record/140495
ER  -