TY  - JOUR
AU  - Brzdak, Patrycja
AU  - Wójcicka, Olga
AU  - Zareba-Koziol, Monika
AU  - Minge, Daniel
AU  - Henneberger, Christian
AU  - Wlodarczyk, Jakub
AU  - Mozrzymas, Jerzy W
AU  - Wójtowicz, Tomasz
TI  - Synaptic Potentiation at Basal and Apical Dendrites of Hippocampal Pyramidal Neurons Involves Activation of a Distinct Set of Extracellular and Intracellular Molecular Cues.
JO  - Cerebral cortex
VL  - 29
IS  - 1
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2020-06836
SP  - 283-304
PY  - 2019
AB  - In the central nervous system, several forms of experience-dependent plasticity, learning and memory require the activity-dependent control of synaptic efficacy. Despite substantial progress in describing synaptic plasticity, mechanisms related to heterogeneity of synaptic functions at local circuits remain elusive. Here we studied the functional and molecular aspects of hippocampal circuit plasticity by analyzing excitatory synapses at basal and apical dendrites of mouse hippocampal pyramidal cells (CA1 region) in acute brain slices. In the past decade, activity of metalloproteinases (MMPs) has been implicated as a widespread and critical factor in plasticity mechanisms at various projections in the CNS. However, in the present study we discovered that in striking contrast to apical dendrites, synapses located within basal dendrites undergo MMP-independent synaptic potentiation. We demonstrate that synapse-specific molecular pathway allowing MMPs to rapidly upregulate function of NMDARs in stratum radiatum involved protease activated receptor 1 and intracellular kinases and GTPases activity. In contrast, MMP-independent scaling of synaptic strength in stratum oriens involved dopamine D1/D5 receptors and Src kinases. Results of this study reveal that 2 neighboring synaptic systems differ significantly in extracellular and intracellular cascades that control synaptic gain and provide long-searched transduction pathways relevant for MMP-dependent synaptic plasticity.
KW  - Animals
KW  - Dendrites: physiology
KW  - Extracellular Fluid: physiology
KW  - Hippocampus: cytology
KW  - Hippocampus: physiology
KW  - Intracellular Fluid: physiology
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Organ Culture Techniques
KW  - Pyramidal Cells: physiology
KW  - Synapses: physiology
KW  - Synaptic Potentials: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:29228131
DO  - DOI:10.1093/cercor/bhx324
UR  - https://pub.dzne.de/record/140514
ER  -