% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Brzdak:140514,
      author       = {Brzdak, Patrycja and Wójcicka, Olga and Zareba-Koziol,
                      Monika and Minge, Daniel and Henneberger, Christian and
                      Wlodarczyk, Jakub and Mozrzymas, Jerzy W and Wójtowicz,
                      Tomasz},
      title        = {{S}ynaptic {P}otentiation at {B}asal and {A}pical
                      {D}endrites of {H}ippocampal {P}yramidal {N}eurons
                      {I}nvolves {A}ctivation of a {D}istinct {S}et of
                      {E}xtracellular and {I}ntracellular {M}olecular {C}ues.},
      journal      = {Cerebral cortex},
      volume       = {29},
      number       = {1},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-06836},
      pages        = {283-304},
      year         = {2019},
      abstract     = {In the central nervous system, several forms of
                      experience-dependent plasticity, learning and memory require
                      the activity-dependent control of synaptic efficacy. Despite
                      substantial progress in describing synaptic plasticity,
                      mechanisms related to heterogeneity of synaptic functions at
                      local circuits remain elusive. Here we studied the
                      functional and molecular aspects of hippocampal circuit
                      plasticity by analyzing excitatory synapses at basal and
                      apical dendrites of mouse hippocampal pyramidal cells (CA1
                      region) in acute brain slices. In the past decade, activity
                      of metalloproteinases (MMPs) has been implicated as a
                      widespread and critical factor in plasticity mechanisms at
                      various projections in the CNS. However, in the present
                      study we discovered that in striking contrast to apical
                      dendrites, synapses located within basal dendrites undergo
                      MMP-independent synaptic potentiation. We demonstrate that
                      synapse-specific molecular pathway allowing MMPs to rapidly
                      upregulate function of NMDARs in stratum radiatum involved
                      protease activated receptor 1 and intracellular kinases and
                      GTPases activity. In contrast, MMP-independent scaling of
                      synaptic strength in stratum oriens involved dopamine D1/D5
                      receptors and Src kinases. Results of this study reveal that
                      2 neighboring synaptic systems differ significantly in
                      extracellular and intracellular cascades that control
                      synaptic gain and provide long-searched transduction
                      pathways relevant for MMP-dependent synaptic plasticity.},
      keywords     = {Animals / Dendrites: physiology / Extracellular Fluid:
                      physiology / Hippocampus: cytology / Hippocampus: physiology
                      / Intracellular Fluid: physiology / Male / Mice / Mice,
                      Inbred C57BL / Organ Culture Techniques / Pyramidal Cells:
                      physiology / Synapses: physiology / Synaptic Potentials:
                      physiology},
      cin          = {U Preclinical Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)7000005},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29228131},
      doi          = {10.1093/cercor/bhx324},
      url          = {https://pub.dzne.de/record/140514},
}