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000140592 0247_ $$2doi$$a10.1002/mrm.27595
000140592 0247_ $$2pmid$$apmid:30506939
000140592 0247_ $$2ISSN$$a0740-3194
000140592 0247_ $$2ISSN$$a1522-2594
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000140592 037__ $$aDZNE-2020-06914
000140592 041__ $$aEnglish
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000140592 1001_ $$0P:(DE-HGF)0$$aDusek, Petr$$b0$$eCorresponding author
000140592 245__ $$aThe choice of embedding media affects image quality, tissue R2* , and susceptibility behaviors in post-mortem brain MR microscopy at 7.0T.
000140592 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2019
000140592 264_1 $$2Crossref$$3online$$bWiley$$c2018-12-02
000140592 264_1 $$2Crossref$$3print$$bWiley$$c2019-04-01
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000140592 520__ $$aThe quality and precision of post-mortem MRI microscopy may vary depending on the embedding medium used. To investigate this, our study evaluated the impact of 5 widely used media on: (1) image quality, (2) contrast of high spatial resolution gradient-echo (T1 and T2* -weighted) MR images, (3) effective transverse relaxation rate (R2* ), and (4) quantitative susceptibility measurements (QSM) of post-mortem brain specimens.Five formaldehyde-fixed brain slices were scanned using 7.0T MRI in: (1) formaldehyde solution (formalin), (2) phosphate-buffered saline (PBS), (3) deuterium oxide (D2 O), (4) perfluoropolyether (Galden), and (5) agarose gel. SNR and contrast-to-noise ratii (SNR/CNR) were calculated for cortex/white matter (WM) and basal ganglia/WM regions. In addition, median R2* and QSM values were extracted from caudate nucleus, putamen, globus pallidus, WM, and cortical regions.PBS, Galden, and agarose returned higher SNR/CNR compared to formalin and D2 O. Formalin fixation, and its use as embedding medium for scanning, increased tissue R2* . Imaging with agarose, D2 O, and Galden returned lower R2* values than PBS (and formalin). No major QSM offsets were observed, although spatial variance was increased (with respect to R2* behaviors) for formalin and agarose.Embedding media affect gradient-echo image quality, R2* , and QSM in differing ways. In this study, PBS embedding was identified as the most stable experimental setup, although by a small margin. Agarose and Galden were preferred to formalin or D2 O embedding. Formalin significantly increased R2* causing noisier data and increased QSM variance.
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000140592 650_2 $$2MeSH$$aAged
000140592 650_2 $$2MeSH$$aAutopsy: instrumentation
000140592 650_2 $$2MeSH$$aAutopsy: methods
000140592 650_2 $$2MeSH$$aBrain: diagnostic imaging
000140592 650_2 $$2MeSH$$aBrain: pathology
000140592 650_2 $$2MeSH$$aBrain Mapping: methods
000140592 650_2 $$2MeSH$$aContrast Media
000140592 650_2 $$2MeSH$$aDeuterium Oxide
000140592 650_2 $$2MeSH$$aEthers
000140592 650_2 $$2MeSH$$aFemale
000140592 650_2 $$2MeSH$$aFluorocarbons
000140592 650_2 $$2MeSH$$aFormaldehyde
000140592 650_2 $$2MeSH$$aHumans
000140592 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000140592 650_2 $$2MeSH$$aMagnetic Resonance Imaging: instrumentation
000140592 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000140592 650_2 $$2MeSH$$aMale
000140592 650_2 $$2MeSH$$aMiddle Aged
000140592 650_2 $$2MeSH$$aPhosphates
000140592 650_2 $$2MeSH$$aSepharose: chemistry
000140592 650_2 $$2MeSH$$aSignal-To-Noise Ratio
000140592 650_2 $$2MeSH$$aSpecimen Handling
000140592 650_2 $$2MeSH$$aTissue Embedding: instrumentation
000140592 7001_ $$aMadai, Vince Istvan$$b1
000140592 7001_ $$aHuelnhagen, Till$$b2
000140592 7001_ $$aBahn, Erik$$b3
000140592 7001_ $$aMatej, Radoslav$$b4
000140592 7001_ $$aSobesky, Jan$$b5
000140592 7001_ $$aNiendorf, Thoralf$$b6
000140592 7001_ $$0P:(DE-2719)2810751$$aAcosta-Cabronero, Julio$$b7$$udzne
000140592 7001_ $$aWuerfel, Jens$$b8
000140592 77318 $$2Crossref$$3journal-article$$a10.1002/mrm.27595$$b : Wiley, 2018-12-02$$n4$$p2688-2701$$tMagnetic Resonance in Medicine$$v81$$x0740-3194$$y2018
000140592 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.27595$$gVol. 81, no. 4, p. 2688 - 2701$$n4$$p2688-2701$$q81:4<2688 - 2701$$tMagnetic resonance in medicine$$v81$$x0740-3194$$y2019
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