000140759 001__ 140759
000140759 005__ 20240430120012.0
000140759 0247_ $$2doi$$a10.7554/eLife.46059
000140759 0247_ $$2pmid$$apmid:31180320
000140759 0247_ $$2pmc$$apmc:PMC6579510
000140759 0247_ $$2altmetric$$aaltmetric:61882442
000140759 037__ $$aDZNE-2020-07081
000140759 041__ $$aEnglish
000140759 082__ $$a600
000140759 1001_ $$0P:(DE-HGF)0$$aWehnekamp, Fabian$$b0
000140759 245__ $$aNanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.
000140759 260__ $$aCambridge$$beLife Sciences Publications$$c2019
000140759 264_1 $$2Crossref$$3online$$beLife Sciences Publications, Ltd$$c2019-06-10
000140759 3367_ $$2DRIVER$$aarticle
000140759 3367_ $$2DataCite$$aOutput Types/Journal article
000140759 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714462136_8222
000140759 3367_ $$2BibTeX$$aARTICLE
000140759 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140759 3367_ $$00$$2EndNote$$aJournal Article
000140759 520__ $$aWe present the development and in vivo application of a feedback-based tracking microscope to follow individual mitochondria in sensory neurons of zebrafish larvae with nanometer precision and millisecond temporal resolution. By combining various technical improvements, we tracked individual mitochondria with unprecedented spatiotemporal resolution over distances of >100 µm. Using these nanoscopic trajectory data, we discriminated five motional states: a fast and a slow directional motion state in both the anterograde and retrograde directions and a stationary state. The transition pattern revealed that, after a pause, mitochondria predominantly persist in the original direction of travel, while transient changes of direction often exhibited longer pauses. Moreover, mitochondria in the vicinity of a second, stationary mitochondria displayed an increased probability to pause. The capability of following and optically manipulating a single organelle with high spatiotemporal resolution in a living organism offers a new approach to elucidating their function in its complete physiological context.
000140759 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000140759 542__ $$2Crossref$$i2019-06-10$$uhttp://creativecommons.org/licenses/by/4.0/
000140759 588__ $$aDataset connected to CrossRef, PubMed,
000140759 650_2 $$2MeSH$$aAnimals
000140759 650_2 $$2MeSH$$aAxons: metabolism
000140759 650_2 $$2MeSH$$aBiological Transport
000140759 650_2 $$2MeSH$$aCell Tracking: methods
000140759 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000140759 650_2 $$2MeSH$$aLarva: metabolism
000140759 650_2 $$2MeSH$$aMicroscopy, Confocal: methods
000140759 650_2 $$2MeSH$$aMitochondria: metabolism
000140759 650_2 $$2MeSH$$aNanotechnology: methods
000140759 650_2 $$2MeSH$$aSensory Receptor Cells: metabolism
000140759 650_2 $$2MeSH$$aVertebrates: metabolism
000140759 650_2 $$2MeSH$$aZebrafish: metabolism
000140759 7001_ $$0P:(DE-2719)9000910$$aPlucińska, Gabriela$$b1$$udzne
000140759 7001_ $$0P:(DE-2719)9000912$$aThong, Rachel$$b2$$udzne
000140759 7001_ $$0P:(DE-2719)2810727$$aMisgeld, Thomas$$b3$$eCorresponding author$$udzne
000140759 7001_ $$0P:(DE-HGF)0$$aLamb, Don C$$b4
000140759 77318 $$2Crossref$$3journal-article$$a10.7554/elife.46059$$b : eLife Sciences Publications, Ltd, 2019-06-10$$teLife$$v8$$x2050-084X$$y2019
000140759 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.46059$$gVol. 8, p. e46059$$pe46059$$q8<e46059$$teLife$$v8$$x2050-084X$$y2019
000140759 8564_ $$uhttps://pub.dzne.de/record/140759/files/DZNE-2020-07081.pdf$$yOpenAccess
000140759 8564_ $$uhttps://pub.dzne.de/record/140759/files/DZNE-2020-07081.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000140759 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579510
000140759 909CO $$ooai:pub.dzne.de:140759$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000140759 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000910$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000140759 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000912$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000140759 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810727$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000140759 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000140759 9141_ $$y2019
000140759 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-23
000140759 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000140759 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bELIFE : 2021$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-09-23T12:20:44Z
000140759 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-09-23T12:20:44Z
000140759 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000140759 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bELIFE : 2021$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-23
000140759 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-23
000140759 9201_ $$0I:(DE-2719)6000016$$kMünchen common$$lMünchen common$$x0
000140759 9201_ $$0I:(DE-2719)1110000-4$$kAG Misgeld$$lNeuronal Cell Biology$$x1
000140759 980__ $$ajournal
000140759 980__ $$aVDB
000140759 980__ $$aUNRESTRICTED
000140759 980__ $$aI:(DE-2719)6000016
000140759 980__ $$aI:(DE-2719)1110000-4
000140759 9801_ $$aFullTexts
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201401070$$o10.1083/jcb.201401070
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/cdd.2012.81$$o10.1038/cdd.2012.81
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0960-9822(92)90896-I$$o10.1016/0960-9822(92)90896-I
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1219206110$$o10.1073/pnas.1219206110
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1556-10.2010$$o10.1523/JNEUROSCI.1556-10.2010
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2015.06.049$$o10.1016/j.cell.2015.06.049
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nm.3520$$o10.1038/nm.3520
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.pneurobio.2006.09.003$$o10.1016/j.pneurobio.2006.09.003
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nprot.2007.291$$o10.1038/nprot.2007.291
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn2631$$o10.1038/nrn2631
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2013.05.021$$o10.1016/j.cell.2013.05.021
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1198-15.2015$$o10.1523/JNEUROSCI.1198-15.2015
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1088/1367-2630/15/7/075008$$o10.1088/1367-2630/15/7/075008
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.11583$$o10.7554/eLife.11583
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/hmg/dds190$$o10.1093/hmg/dds190
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/pdb.top119$$o10.1101/pdb.top119
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41556-019-0317-2$$o10.1038/s41556-019-0317-2
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nmeth818$$o10.1038/nmeth818
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrm2774$$o10.1038/nrm2774
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2010.09.039$$o10.1016/j.neuron.2010.09.039
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/nl1028792$$o10.1021/nl1028792
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0006-3495(94)80601-0$$o10.1016/S0006-3495(94)80601-0
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/cphc.200900436$$o10.1002/cphc.200900436
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/aja.1002030302$$o10.1002/aja.1002030302
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/71338$$o10.1038/71338
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1006/dbio.2001.0242$$o10.1006/dbio.2001.0242
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0955-0674(95)80048-4$$o10.1016/0955-0674(95)80048-4
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/jbio.201100002$$o10.1002/jbio.201100002
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1063/1.2819074$$o10.1063/1.2819074
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1529/biophysj.104.044230$$o10.1529/biophysj.104.044230
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2016.07.064$$o10.1016/j.cub.2016.07.064
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/1096-9861(20001120)427:3<340::AID-CNE2>3.0.CO;2-Y$$o10.1002/1096-9861(20001120)427:3<340::AID-CNE2>3.0.CO;2-Y
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tcb.2009.11.002$$o10.1016/j.tcb.2009.11.002
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature02293$$o10.1038/nature02293
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/nl0723376$$o10.1021/nl0723376
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/B978-0-12-391857-4.00009-4$$o10.1016/B978-0-12-391857-4.00009-4
000140759 999C5 $$2Crossref$$oMilo Cell Biology by the Numbers 2016$$tCell Biology by the Numbers$$y2016
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nmeth1055$$o10.1038/nmeth1055
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2017.09.055$$o10.1016/j.neuron.2017.09.055
000140759 999C5 $$2Crossref$$oMorris 1993$$y1993
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.131.5.1315$$o10.1083/jcb.131.5.1315
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0960-9822(00)00048-8$$o10.1016/S0960-9822(00)00048-8
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1331-13.2013$$o10.1523/JNEUROSCI.1331-13.2013
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jtbi.2008.09.009$$o10.1016/j.jtbi.2008.09.009
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/ejn.12263$$o10.1111/ejn.12263
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0095-11.2011$$o10.1523/JNEUROSCI.0095-11.2011
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1621-10.2010$$o10.1523/JNEUROSCI.1621-10.2010
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2014.06.007$$o10.1016/j.cell.2014.06.007
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms8874$$o10.1038/ncomms8874
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1327-12.2012$$o10.1523/JNEUROSCI.1327-12.2012
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.conb.2016.06.006$$o10.1016/j.conb.2016.06.006
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0042-6989(01)00284-X$$o10.1016/S0042-6989(01)00284-X
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.4161$$o10.1038/nn.4161
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pbio.1001754$$o10.1371/journal.pbio.1001754
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.053850$$o10.1242/jcs.053850
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/acs.nanolett.5b01396$$o10.1021/acs.nanolett.5b01396
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201312123$$o10.1083/jcb.201312123
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn3156$$o10.1038/nrn3156
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2016.07.033$$o10.1016/j.cub.2016.07.033
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.celrep.2013.11.022$$o10.1016/j.celrep.2013.11.022
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gku1194$$o10.1093/nar/gku1194
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0508511103$$o10.1073/pnas.0508511103
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature14128$$o10.1038/nature14128
000140759 999C5 $$2Crossref$$oWehnekamp GitLab 2015$$tGitLab$$y2015
000140759 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nnano.2014.12$$o10.1038/nnano.2014.12