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@ARTICLE{Knauer:140884,
      author       = {Knauer, Beate and Yoshida, Motoharu},
      title        = {{S}witching between persistent firing and depolarization
                      block in individual rat {CA}1 pyramidal neurons.},
      journal      = {Hippocampus},
      volume       = {29},
      number       = {9},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-07206},
      pages        = {817-835},
      year         = {2019},
      abstract     = {The hippocampal formation plays a role in mnemonic tasks
                      and epileptic discharges in vivo. In vitro, these functions
                      and malfunctions may relate to persistent firing (PF) and
                      depolarization block (DB), respectively. Pyramidal neurons
                      of the CA1 field have previously been reported to engage in
                      either PF or DB during cholinergic stimulation. However, it
                      is unknown whether these cells constitute disparate
                      populations of neurons. Furthermore, it is unclear which
                      cell-specific peculiarities may mediate their diverse
                      response properties. However, it has not been shown whether
                      individual CA1 pyramidal neurons can switch between PF and
                      DB states. Here, we used whole cell patch clamp in the
                      current clamp mode on in vitro CA1 pyramidal neurons from
                      acutely sliced rat tissue to test various intrinsic
                      properties which may provoke individual cells to switch
                      between PF and DB. We found that individual cells could
                      switch from PF to DB, in a cholinergic agonist concentration
                      dependent manner and depending on the parameters of
                      stimulation. We also demonstrate involvement of TRPC and
                      potassium channels in this switching. Finally, we report
                      that the probability for DB was more pronounced in the
                      proximal than in the distal half of CA1. These findings
                      offer a potential mechanism for the stronger spatial
                      modulation in proximal, compared to distal CA1, as place
                      field formation was shown to be affected by DB. Taken
                      together, our results suggest that PF and DB are not
                      mutually exclusive response properties of individual
                      neurons. Rather, a cell's response mode depends on a variety
                      of intrinsic properties, and modulation of these properties
                      enables switching between PF and DB.},
      keywords     = {Animals / CA1 Region, Hippocampal: cytology / CA1 Region,
                      Hippocampal: drug effects / CA1 Region, Hippocampal:
                      physiology / Carbachol: pharmacology / Dose-Response
                      Relationship, Drug / Electrophysiological Phenomena: drug
                      effects / Electrophysiological Phenomena: physiology /
                      Female / In Vitro Techniques / Male / Membrane Potentials:
                      drug effects / Muscarinic Agonists: pharmacology /
                      Patch-Clamp Techniques / Potassium Channels: metabolism /
                      Pyramidal Cells: drug effects / Pyramidal Cells: physiology
                      / Rats / Rats, Long-Evans / TRPC Cation Channels:
                      antagonists $\&$ inhibitors / TRPC Cation Channels:
                      metabolism},
      cin          = {AG Yoshida},
      ddc          = {610},
      cid          = {I:(DE-2719)1310011},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30794330},
      doi          = {10.1002/hipo.23078},
      url          = {https://pub.dzne.de/record/140884},
}