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000140886 1001_ $$0P:(DE-2719)9000937$$aLeiter, Odette$$b0$$eFirst author
000140886 245__ $$aThe systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.
000140886 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2019
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000140886 520__ $$aPhysical exercise has well-established anti-inflammatory effects, with neuro-immunological crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on brain health. Here, we used physical exercise, a strong positive modulator of adult hippocampal neurogenesis, as a model to identify immune molecules that are secreted into the blood stream, which could potentially mediate this process. Proteomic profiling of mouse plasma showed that levels of the chemokine lymphotactin (XCL1) were elevated after four days of running. We found that XCL1 treatment of primary cells isolated from both the dentate gyrus and the subventricular zone of the adult mice led to an increase in the number of neurospheres and neuronal differentiation in neurospheres derived from the dentate gyrus. In contrast, primary dentate gyrus cells isolated from XCL1 knockout mice formed fewer neurospheres and exhibited a reduced neuronal differentiation potential. XCL1 supplementation in a dentate gyrus-derived neural precursor cell line promoted neuronal differentiation and resulted in lower cell motility and a reduced number of cells in the S phase of the cell cycle. This work suggests an additional function of the chemokine XCL1 in the brain and underpins the complexity of neuro-immune interactions that contribute to the regulation of adult hippocampal neurogenesis.
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000140886 542__ $$2Crossref$$i2019-08-14$$uhttps://creativecommons.org/licenses/by/4.0
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000140886 650_2 $$2MeSH$$aAnimals
000140886 650_2 $$2MeSH$$aCell Differentiation
000140886 650_2 $$2MeSH$$aCell Proliferation
000140886 650_2 $$2MeSH$$aChemokines, C: metabolism
000140886 650_2 $$2MeSH$$aHippocampus: cytology
000140886 650_2 $$2MeSH$$aHippocampus: metabolism
000140886 650_2 $$2MeSH$$aIn Vitro Techniques
000140886 650_2 $$2MeSH$$aMice
000140886 650_2 $$2MeSH$$aMice, Knockout
000140886 650_2 $$2MeSH$$aNeurons: cytology
000140886 650_2 $$2MeSH$$aPhysical Conditioning, Animal
000140886 7001_ $$0P:(DE-2719)2811412$$aBernas, Stefanie N$$b1
000140886 7001_ $$aSeidemann, Suse$$b2
000140886 7001_ $$0P:(DE-2719)2812530$$aOverall, Rupert W$$b3
000140886 7001_ $$aHorenburg, Cindy$$b4
000140886 7001_ $$aKowal, Susann$$b5
000140886 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b6
000140886 7001_ $$0P:(DE-2719)9000335$$aWalker, Tara$$b7$$eLast author
000140886 77318 $$2Crossref$$3journal-article$$a10.1038/s41598-019-48360-5$$b : Springer Science and Business Media LLC, 2019-08-14$$n1$$p11831$$tScientific Reports$$v9$$x2045-2322$$y2019
000140886 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-019-48360-5$$gVol. 9, no. 1, p. 11831$$n1$$p11831$$q9:1<11831$$tScientific reports$$v9$$x2045-2322$$y2019
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