Journal Article

DZNE-2020-07208

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.

Leiter, O. (First author)DZNE* ; Bernas, S. N.DZNE* ; Seidemann, S. ; Overall, R. W.DZNE* ; Horenburg, C. ; Kowal, S. ; Kempermann, G.DZNE* ; Walker, T. (Last author)DZNE*

2019
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-019-48360-5

Abstract: Physical exercise has well-established anti-inflammatory effects, with neuro-immunological crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on brain health. Here, we used physical exercise, a strong positive modulator of adult hippocampal neurogenesis, as a model to identify immune molecules that are secreted into the blood stream, which could potentially mediate this process. Proteomic profiling of mouse plasma showed that levels of the chemokine lymphotactin (XCL1) were elevated after four days of running. We found that XCL1 treatment of primary cells isolated from both the dentate gyrus and the subventricular zone of the adult mice led to an increase in the number of neurospheres and neuronal differentiation in neurospheres derived from the dentate gyrus. In contrast, primary dentate gyrus cells isolated from XCL1 knockout mice formed fewer neurospheres and exhibited a reduced neuronal differentiation potential. XCL1 supplementation in a dentate gyrus-derived neural precursor cell line promoted neuronal differentiation and resulted in lower cell motility and a reduced number of cells in the S phase of the cell cycle. This work suggests an additional function of the chemokine XCL1 in the brain and underpins the complexity of neuro-immune interactions that contribute to the regulation of adult hippocampal neurogenesis.

Keyword(s): Animals (MeSH) ; Cell Differentiation (MeSH) ; Cell Proliferation (MeSH) ; Chemokines, C: metabolism (MeSH) ; Hippocampus: cytology (MeSH) ; Hippocampus: metabolism (MeSH) ; In Vitro Techniques (MeSH) ; Mice (MeSH) ; Mice, Knockout (MeSH) ; Neurons: cytology (MeSH) ; Physical Conditioning, Animal (MeSH)

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Contributing Institute(s):

1. Dresden Pre 2020 (Dresden Pre 2020)
2. Adult Neurogenesis (AG Kempermann 1)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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