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@ARTICLE{Leiter:140886,
      author       = {Leiter, Odette and Bernas, Stefanie N and Seidemann, Suse
                      and Overall, Rupert W and Horenburg, Cindy and Kowal, Susann
                      and Kempermann, Gerd and Walker, Tara},
      title        = {{T}he systemic exercise-released chemokine
                      lymphotactin/{XCL}1 modulates in vitro adult hippocampal
                      precursor cell proliferation and neuronal differentiation.},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2020-07208},
      pages        = {11831},
      year         = {2019},
      abstract     = {Physical exercise has well-established anti-inflammatory
                      effects, with neuro-immunological crosstalk being proposed
                      as a mechanism underlying the beneficial effects of exercise
                      on brain health. Here, we used physical exercise, a strong
                      positive modulator of adult hippocampal neurogenesis, as a
                      model to identify immune molecules that are secreted into
                      the blood stream, which could potentially mediate this
                      process. Proteomic profiling of mouse plasma showed that
                      levels of the chemokine lymphotactin (XCL1) were elevated
                      after four days of running. We found that XCL1 treatment of
                      primary cells isolated from both the dentate gyrus and the
                      subventricular zone of the adult mice led to an increase in
                      the number of neurospheres and neuronal differentiation in
                      neurospheres derived from the dentate gyrus. In contrast,
                      primary dentate gyrus cells isolated from XCL1 knockout mice
                      formed fewer neurospheres and exhibited a reduced neuronal
                      differentiation potential. XCL1 supplementation in a dentate
                      gyrus-derived neural precursor cell line promoted neuronal
                      differentiation and resulted in lower cell motility and a
                      reduced number of cells in the S phase of the cell cycle.
                      This work suggests an additional function of the chemokine
                      XCL1 in the brain and underpins the complexity of
                      neuro-immune interactions that contribute to the regulation
                      of adult hippocampal neurogenesis.},
      keywords     = {Animals / Cell Differentiation / Cell Proliferation /
                      Chemokines, C: metabolism / Hippocampus: cytology /
                      Hippocampus: metabolism / In Vitro Techniques / Mice / Mice,
                      Knockout / Neurons: cytology / Physical Conditioning,
                      Animal},
      cin          = {Dresden Pre 2020 / AG Kempermann 1},
      ddc          = {600},
      cid          = {I:(DE-2719)6000013 / I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31413355},
      pmc          = {pmc:PMC6694144},
      doi          = {10.1038/s41598-019-48360-5},
      url          = {https://pub.dzne.de/record/140886},
}