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| Journal Article (Review Article) | DZNE-2020-07209 |
; ;
2019
Ovid
[S.l.]
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Please use a persistent id in citations: doi:10.1097/QCO.0000000000000540
Abstract: Immune memory is essential for host defense against invaders and it is also used as a basis for vaccine development. For these reasons, it is crucial to understand its molecular basis. In this review, we describe recent findings on memory characteristics of innate-like lymphocytes and its contribution to host protection.(Figure is included in full-text article.) RECENT FINDINGS: In addition to adaptive immune cells, innate cells are also able to mount memory responses through a process called 'trained immunity.' Importantly, the lymphoid lineage is not restricted to cells carrying specific T-cell or B-cell receptors, but include cells with germline-encoded receptors. Recent studies show that these innate-like lymphocytes are able to generate efficient recall responses to reinfection. In different circumstances and depending on the cell type, innate-like lymphocyte memory can be antigen-specific or unspecific. Epigenetic changes accompany the generation of memory in these cells, but are still poorly defined.Immune memory is not restricted to antigen-specific cells, but also encompass different populations of innate immune cells. Innate-like lymphocytes embrace features of both innate and adaptive immune memory, and thus bridge adaptive and innate immune characteristics.
Keyword(s): Animals (MeSH) ; Communicable Diseases: immunology (MeSH) ; Humans (MeSH) ; Immunity, Innate (MeSH) ; Immunologic Memory (MeSH) ; Lymphocytes: immunology (MeSH)
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