TY  - JOUR
AU  - Maetzler, Walter
AU  - Rattay, Tim W
AU  - Hobert, Markus A
AU  - Synofzik, Matthis
AU  - Bader, Angela
AU  - Berg, Daniela
AU  - Schaeffer, Eva
AU  - Rommel, Natalie
AU  - Devos, David
AU  - Bloem, Bastiaan R
AU  - Bender, Benjamin
TI  - Freezing of Swallowing.
JO  - Movement disorders clinical practice
VL  - 3
IS  - 5
SN  - 2330-1619
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2020-07303
SP  - 490-493
PY  - 2016
AB  - Swallowing deficits and freezing phenomena represent severe parkinsonian features. Freezing as a symptom occurring during swallowing has not been reported on yet.We report on 3 patients with probable PSP-parkinsonism (PSP-P) who manifested freezing of swallowing (FOS).All 3 patients experienced severe weight loss in recent months. At examination, 1 patient had freezing of gait. Video fluoroscopy showed nonfunctional trembling movements of the tongue and palate during chewing and volitional swallowing, with a 6- to 8-Hz frequency that is typical for freezing episodes during walking and finger tapping. These freezing episodes were accompanied by impaired oral bolus transportation. The pharyngeal phase was not relevantly affected.FOS represents a novel disease feature of PSP-P. The feature may have fundamental, but potentially treatable, consequences for patients' health and quality of life and may be considered in patients with degenerative parkinsonism who experience severe and unexplained weight loss.
LB  - PUB:(DE-HGF)16
C6  - pmid:30868092
C2  - pmc:PMC6400494
DO  - DOI:10.1002/mdc3.12314
UR  - https://pub.dzne.de/record/140981
ER  -