%0 Journal Article
%A Anwarullah, Anwarullah
%A Aslam, Muhammad
%A Badshah, Mazhar
%A Abbasi, Rashda
%A Sultan, Aneesa
%A Khan, Kafaitullah
%A Ahmad, Nafees
%A Engelhardt, Jakob
%T Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.
%J Genes and environment
%V 39
%N 1
%@ 1880-7062
%C [London]
%I BioMed Central
%M DZNE-2020-07691
%P 18
%D 2017
%X Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28680508
%2 pmc:PMC5493842
%R 10.1186/s41021-017-0078-8
%U https://pub.dzne.de/record/141369