Journal Article

DZNE-2020-07691

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.

Anwarullah, A. (First author)DZNE* ; Aslam, M.DZNE* ; Badshah, M. ; Abbasi, R. ; Sultan, A. ; Khan, K. ; Ahmad, N. ; Engelhardt, J. (Last author)DZNE*

2017
BioMed Central [London]

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Please use a persistent id in citations: doi:10.1186/s41021-017-0078-8

Abstract: Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.

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Contributing Institute(s):

1. Synaptic Signalling and Neurodegeneration (AG Engelhardt)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2017

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Database coverage:
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