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000141369 037__ $$aDZNE-2020-07691
000141369 041__ $$aEnglish
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000141369 1001_ $$0P:(DE-2719)9000009$$aAnwarullah, Anwarullah$$b0$$eFirst author$$udzne
000141369 245__ $$aFurther evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.
000141369 260__ $$a[London]$$bBioMed Central$$c2017
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000141369 520__ $$aGenetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.
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000141369 7001_ $$0P:(DE-2719)2810579$$aAslam, Muhammad$$b1$$udzne
000141369 7001_ $$aBadshah, Mazhar$$b2
000141369 7001_ $$aAbbasi, Rashda$$b3
000141369 7001_ $$aSultan, Aneesa$$b4
000141369 7001_ $$aKhan, Kafaitullah$$b5
000141369 7001_ $$aAhmad, Nafees$$b6
000141369 7001_ $$0P:(DE-2719)2810460$$aEngelhardt, Jakob$$b7$$eLast author$$udzne
000141369 77318 $$2Crossref$$3journal-article$$a10.1186/s41021-017-0078-8$$b : Springer Science and Business Media LLC, 2017-07-01$$n1$$p18$$tGenes and Environment$$v39$$x1880-7062$$y2017
000141369 773__ $$0PERI:(DE-600)2269162-5$$a10.1186/s41021-017-0078-8$$gVol. 39, no. 1, p. 18$$n1$$p18$$q39:1<18$$tGenes and environment$$v39$$x1880-7062$$y2017
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