TY  - JOUR
AU  - Anwarullah, Anwarullah
AU  - Aslam, Muhammad
AU  - Badshah, Mazhar
AU  - Abbasi, Rashda
AU  - Sultan, Aneesa
AU  - Khan, Kafaitullah
AU  - Ahmad, Nafees
AU  - Engelhardt, Jakob
TI  - Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.
JO  - Genes and environment
VL  - 39
IS  - 1
SN  - 1880-7062
CY  - [London]
PB  - BioMed Central
M1  - DZNE-2020-07691
SP  - 18
PY  - 2017
AB  - Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.
LB  - PUB:(DE-HGF)16
C6  - pmid:28680508
C2  - pmc:PMC5493842
DO  - DOI:10.1186/s41021-017-0078-8
UR  - https://pub.dzne.de/record/141369
ER  -