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@ARTICLE{Anwarullah:141369,
      author       = {Anwarullah, Anwarullah and Aslam, Muhammad and Badshah,
                      Mazhar and Abbasi, Rashda and Sultan, Aneesa and Khan,
                      Kafaitullah and Ahmad, Nafees and Engelhardt, Jakob},
      title        = {{F}urther evidence for the association of {CYP}2{D}6*4 gene
                      polymorphism with {P}arkinson's disease: a case control
                      study.},
      journal      = {Genes and environment},
      volume       = {39},
      number       = {1},
      issn         = {1880-7062},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2020-07691},
      pages        = {18},
      year         = {2017},
      abstract     = {Genetic and environmental risk factors play an important
                      role for the susceptibility to sporadic Parkinson's disease
                      (PD). It was hypothesized that a splice variant of the
                      CYP2D6 gene (CYP2D6*4 allele) is associated with PD because
                      it alters the ability to metabolize toxins and in particular
                      neurotoxins. CYP2D6 codes for the drug metabolizing enzyme
                      debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in
                      an undetectable enzyme activity and consequently in a
                      reduction in metabolism of some toxins.Some of agricultural
                      chemicals have neurotoxic potential and CYP2D6 is involved
                      in their detoxification. Thus, we conducted a case control
                      study to investigate the association of the CYP2D6*4 with PD
                      in a Pakistani subpopulation that is known to be exposed to
                      high levels of some agricultural pesticides, insecticides
                      and herbicides.We found a significantly higher allele and
                      genotype frequency of the CYP2D6*4 variant in 174 sporadic
                      PD patients when compared to 200 controls. In addition,
                      there was a trend to an earlier age of PD onset and a tremor
                      dominant phenotype in CYP2D6*4 variant carriers.Our data
                      provide further evidence that a poor metabolizer status may
                      increase the risk to develop PD especially in populations
                      that are exposed to environmental toxins.},
      cin          = {AG Engelhardt},
      ddc          = {690},
      cid          = {I:(DE-2719)1013023},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28680508},
      pmc          = {pmc:PMC5493842},
      doi          = {10.1186/s41021-017-0078-8},
      url          = {https://pub.dzne.de/record/141369},
}