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| 001 | 141369 | ||
| 005 | 20240416115859.0 | ||
| 024 | 7 | _ | |a 10.1186/s41021-017-0078-8 |2 doi |
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| 037 | _ | _ | |a DZNE-2020-07691 |
| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Anwarullah, Anwarullah |0 P:(DE-2719)9000009 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study. |
| 260 | _ | _ | |a [London] |c 2017 |b BioMed Central |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2017-07-01 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-12-01 |
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| 520 | _ | _ | |a Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins.Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides.We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers.Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins. |
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| 700 | 1 | _ | |a Badshah, Mazhar |b 2 |
| 700 | 1 | _ | |a Abbasi, Rashda |b 3 |
| 700 | 1 | _ | |a Sultan, Aneesa |b 4 |
| 700 | 1 | _ | |a Khan, Kafaitullah |b 5 |
| 700 | 1 | _ | |a Ahmad, Nafees |b 6 |
| 700 | 1 | _ | |a Engelhardt, Jakob |0 P:(DE-2719)2810460 |b 7 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1186/s41021-017-0078-8 |b : Springer Science and Business Media LLC, 2017-07-01 |n 1 |p 18 |3 journal-article |2 Crossref |t Genes and Environment |v 39 |y 2017 |x 1880-7062 |
| 773 | _ | _ | |a 10.1186/s41021-017-0078-8 |g Vol. 39, no. 1, p. 18 |0 PERI:(DE-600)2269162-5 |n 1 |q 39:1<18 |p 18 |t Genes and environment |v 39 |y 2017 |x 1880-7062 |
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