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000141402 0247_ $$2doi$$a10.15252/embr.201438869
000141402 0247_ $$2pmid$$apmid:24820036
000141402 0247_ $$2pmc$$apmc:PMC4196979
000141402 0247_ $$2ISSN$$a1469-221X
000141402 0247_ $$2ISSN$$a1469-3178
000141402 0247_ $$2altmetric$$aaltmetric:2345099
000141402 037__ $$aDZNE-2020-07724
000141402 041__ $$aEnglish
000141402 082__ $$a570
000141402 1001_ $$aSchiffer, Christian$$b0
000141402 245__ $$aDirect action of endocrine disrupting chemicals on human sperm.
000141402 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2014
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000141402 264_1 $$2Crossref$$3print$$bEMBO$$c2014-07-01
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000141402 520__ $$aSynthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.
000141402 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000141402 542__ $$2Crossref$$i2014-05-12$$uhttp://onlinelibrary.wiley.com/termsAndConditions#vor
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000141402 650_7 $$2NLM Chemicals$$aCalcium Channels
000141402 650_7 $$2NLM Chemicals$$aEndocrine Disruptors
000141402 650_7 $$2NLM Chemicals$$aLigands
000141402 650_7 $$0SY7Q814VUP$$2NLM Chemicals$$aCalcium
000141402 650_2 $$2MeSH$$aAcrosome: metabolism
000141402 650_2 $$2MeSH$$aAction Potentials: drug effects
000141402 650_2 $$2MeSH$$aBinding, Competitive
000141402 650_2 $$2MeSH$$aCalcium: metabolism
000141402 650_2 $$2MeSH$$aCalcium Channels: metabolism
000141402 650_2 $$2MeSH$$aCalcium Signaling: drug effects
000141402 650_2 $$2MeSH$$aEndocrine Disruptors: chemistry
000141402 650_2 $$2MeSH$$aEndocrine Disruptors: pharmacology
000141402 650_2 $$2MeSH$$aExocytosis: drug effects
000141402 650_2 $$2MeSH$$aHumans
000141402 650_2 $$2MeSH$$aLigands
000141402 650_2 $$2MeSH$$aMale
000141402 650_2 $$2MeSH$$aProtein Binding
000141402 650_2 $$2MeSH$$aSperm Motility: drug effects
000141402 650_2 $$2MeSH$$aSpermatozoa: drug effects
000141402 650_2 $$2MeSH$$aSpermatozoa: physiology
000141402 7001_ $$aMüller, Astrid$$b1
000141402 7001_ $$aEgeberg, Dorte L$$b2
000141402 7001_ $$aAlvarez, Luis$$b3
000141402 7001_ $$0P:(DE-2719)2810811$$aBrenker, Christoph$$b4$$udzne
000141402 7001_ $$aRehfeld, Anders$$b5
000141402 7001_ $$aFrederiksen, Hanne$$b6
000141402 7001_ $$aWäschle, Benjamin$$b7
000141402 7001_ $$aKaupp, U Benjamin$$b8
000141402 7001_ $$aBalbach, Melanie$$b9
000141402 7001_ $$aWachten, Dagmar$$b10
000141402 7001_ $$0P:(DE-HGF)0$$aSkakkebaek, Niels E$$b11$$eCorresponding author
000141402 7001_ $$aAlmstrup, Kristian$$b12
000141402 7001_ $$aStrünker, Timo$$b13
000141402 77318 $$2Crossref$$3journal-article$$a10.15252/embr.201438869$$b : EMBO, 2014-05-12$$n7$$p758-765$$tEMBO reports$$v15$$x1469-221X$$y2014
000141402 773__ $$0PERI:(DE-600)2025376-X$$a10.15252/embr.201438869$$gVol. 15, no. 7, p. 758 - 765$$n7$$p758-765$$q15:7<758 - 765$$tEMBO reports$$v15$$x1469-221X$$y2014
000141402 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196979
000141402 8564_ $$uhttps://pub.dzne.de/record/141402/files/DZNE-2020-07724_Restricted.pdf
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