Journal Article

DZNE-2020-07724

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Direct action of endocrine disrupting chemicals on human sperm.

Schiffer, C. ; Müller, A. ; Egeberg, D. L. ; Alvarez, L. ; Brenker, C.DZNE* ; Rehfeld, A. ; Frederiksen, H. ; Wäschle, B. ; Kaupp, U. B. ; Balbach, M. ; Wachten, D. ; Skakkebaek, N. E. (Corresponding author) ; Almstrup, K. ; Strünker, T.

2014
Wiley Hoboken, NJ [u.a.]

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Please use a persistent id in citations: doi:10.15252/embr.201438869

Abstract: Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

Keyword(s): Acrosome: metabolism (MeSH) ; Action Potentials: drug effects (MeSH) ; Binding, Competitive (MeSH) ; Calcium: metabolism (MeSH) ; Calcium Channels: metabolism (MeSH) ; Calcium Signaling: drug effects (MeSH) ; Endocrine Disruptors: chemistry (MeSH) ; Endocrine Disruptors: pharmacology (MeSH) ; Exocytosis: drug effects (MeSH) ; Humans (MeSH) ; Ligands (MeSH) ; Male (MeSH) ; Protein Binding (MeSH) ; Sperm Motility: drug effects (MeSH) ; Spermatozoa: drug effects (MeSH) ; Spermatozoa: physiology (MeSH) ; Calcium Channels ; Endocrine Disruptors ; Ligands ; Calcium

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Contributing Institute(s):

1. Cryo-electron microscopy and tomography (AG Alamoudi)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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