TY  - JOUR
AU  - Schiffer, Christian
AU  - Müller, Astrid
AU  - Egeberg, Dorte L
AU  - Alvarez, Luis
AU  - Brenker, Christoph
AU  - Rehfeld, Anders
AU  - Frederiksen, Hanne
AU  - Wäschle, Benjamin
AU  - Kaupp, U Benjamin
AU  - Balbach, Melanie
AU  - Wachten, Dagmar
AU  - Skakkebaek, Niels E
AU  - Almstrup, Kristian
AU  - Strünker, Timo
TI  - Direct action of endocrine disrupting chemicals on human sperm.
JO  - EMBO reports
VL  - 15
IS  - 7
SN  - 1469-221X
CY  - Hoboken, NJ [u.a.]
PB  - Wiley
M1  - DZNE-2020-07724
SP  - 758-765
PY  - 2014
AB  - Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.
KW  - Acrosome: metabolism
KW  - Action Potentials: drug effects
KW  - Binding, Competitive
KW  - Calcium: metabolism
KW  - Calcium Channels: metabolism
KW  - Calcium Signaling: drug effects
KW  - Endocrine Disruptors: chemistry
KW  - Endocrine Disruptors: pharmacology
KW  - Exocytosis: drug effects
KW  - Humans
KW  - Ligands
KW  - Male
KW  - Protein Binding
KW  - Sperm Motility: drug effects
KW  - Spermatozoa: drug effects
KW  - Spermatozoa: physiology
KW  - Calcium Channels (NLM Chemicals)
KW  - Endocrine Disruptors (NLM Chemicals)
KW  - Ligands (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24820036
C2  - pmc:PMC4196979
DO  - DOI:10.15252/embr.201438869
UR  - https://pub.dzne.de/record/141402
ER  -