% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schiffer:141402,
      author       = {Schiffer, Christian and Müller, Astrid and Egeberg, Dorte
                      L and Alvarez, Luis and Brenker, Christoph and Rehfeld,
                      Anders and Frederiksen, Hanne and Wäschle, Benjamin and
                      Kaupp, U Benjamin and Balbach, Melanie and Wachten, Dagmar
                      and Skakkebaek, Niels E and Almstrup, Kristian and
                      Strünker, Timo},
      title        = {{D}irect action of endocrine disrupting chemicals on human
                      sperm.},
      journal      = {EMBO reports},
      volume       = {15},
      number       = {7},
      issn         = {1469-221X},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-07724},
      pages        = {758-765},
      year         = {2014},
      abstract     = {Synthetic endocrine disrupting chemicals (EDCs),
                      omnipresent in food, household, and personal care products,
                      have been implicated in adverse trends in human
                      reproduction, including infertility and increasing demand
                      for assisted reproduction. Here, we study the action of 96
                      ubiquitous EDCs on human sperm. We show that structurally
                      diverse EDCs activate the sperm-specific CatSper channel
                      and, thereby, evoke an intracellular Ca(2+) increase, a
                      motility response, and acrosomal exocytosis. Moreover, EDCs
                      desensitize sperm for physiological CatSper ligands and
                      cooperate in low-dose mixtures to elevate Ca(2+) levels in
                      sperm. We conclude that EDCs interfere with various sperm
                      functions and, thereby, might impair human fertilization.},
      keywords     = {Acrosome: metabolism / Action Potentials: drug effects /
                      Binding, Competitive / Calcium: metabolism / Calcium
                      Channels: metabolism / Calcium Signaling: drug effects /
                      Endocrine Disruptors: chemistry / Endocrine Disruptors:
                      pharmacology / Exocytosis: drug effects / Humans / Ligands /
                      Male / Protein Binding / Sperm Motility: drug effects /
                      Spermatozoa: drug effects / Spermatozoa: physiology /
                      Calcium Channels (NLM Chemicals) / Endocrine Disruptors (NLM
                      Chemicals) / Ligands (NLM Chemicals) / Calcium (NLM
                      Chemicals)},
      cin          = {AG Alamoudi},
      ddc          = {570},
      cid          = {I:(DE-2719)1013012},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24820036},
      pmc          = {pmc:PMC4196979},
      doi          = {10.15252/embr.201438869},
      url          = {https://pub.dzne.de/record/141402},
}