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| 001 | 141402 | ||
| 005 | 20250325130135.0 | ||
| 024 | 7 | _ | |a 10.15252/embr.201438869 |2 doi |
| 024 | 7 | _ | |a pmid:24820036 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4196979 |2 pmc |
| 024 | 7 | _ | |a 1469-221X |2 ISSN |
| 024 | 7 | _ | |a 1469-3178 |2 ISSN |
| 024 | 7 | _ | |a altmetric:2345099 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-07724 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Schiffer, Christian |b 0 |
| 245 | _ | _ | |a Direct action of endocrine disrupting chemicals on human sperm. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2014 |b Wiley |
| 264 | _ | 1 | |3 online |2 Crossref |b EMBO |c 2014-05-12 |
| 264 | _ | 1 | |3 print |2 Crossref |b EMBO |c 2014-07-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1742904038_32038 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2014-05-12 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2014-05-12 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Calcium Channels |2 NLM Chemicals |
| 650 | _ | 7 | |a Endocrine Disruptors |2 NLM Chemicals |
| 650 | _ | 7 | |a Ligands |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 650 | _ | 2 | |a Acrosome: metabolism |2 MeSH |
| 650 | _ | 2 | |a Action Potentials: drug effects |2 MeSH |
| 650 | _ | 2 | |a Binding, Competitive |2 MeSH |
| 650 | _ | 2 | |a Calcium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Calcium Channels: metabolism |2 MeSH |
| 650 | _ | 2 | |a Calcium Signaling: drug effects |2 MeSH |
| 650 | _ | 2 | |a Endocrine Disruptors: chemistry |2 MeSH |
| 650 | _ | 2 | |a Endocrine Disruptors: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Exocytosis: drug effects |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Ligands |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Protein Binding |2 MeSH |
| 650 | _ | 2 | |a Sperm Motility: drug effects |2 MeSH |
| 650 | _ | 2 | |a Spermatozoa: drug effects |2 MeSH |
| 650 | _ | 2 | |a Spermatozoa: physiology |2 MeSH |
| 700 | 1 | _ | |a Müller, Astrid |b 1 |
| 700 | 1 | _ | |a Egeberg, Dorte L |b 2 |
| 700 | 1 | _ | |a Alvarez, Luis |b 3 |
| 700 | 1 | _ | |a Brenker, Christoph |0 P:(DE-2719)2810811 |b 4 |u dzne |
| 700 | 1 | _ | |a Rehfeld, Anders |b 5 |
| 700 | 1 | _ | |a Frederiksen, Hanne |b 6 |
| 700 | 1 | _ | |a Wäschle, Benjamin |b 7 |
| 700 | 1 | _ | |a Kaupp, U Benjamin |b 8 |
| 700 | 1 | _ | |a Balbach, Melanie |b 9 |
| 700 | 1 | _ | |a Wachten, Dagmar |b 10 |
| 700 | 1 | _ | |a Skakkebaek, Niels E |0 P:(DE-HGF)0 |b 11 |e Corresponding author |
| 700 | 1 | _ | |a Almstrup, Kristian |b 12 |
| 700 | 1 | _ | |a Strünker, Timo |b 13 |
| 773 | 1 | 8 | |a 10.15252/embr.201438869 |b : EMBO, 2014-05-12 |n 7 |p 758-765 |3 journal-article |2 Crossref |t EMBO reports |v 15 |y 2014 |x 1469-221X |
| 773 | _ | _ | |a 10.15252/embr.201438869 |g Vol. 15, no. 7, p. 758 - 765 |0 PERI:(DE-600)2025376-X |n 7 |q 15:7<758 - 765 |p 758-765 |t EMBO reports |v 15 |y 2014 |x 1469-221X |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196979 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141402/files/DZNE-2020-07724_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141402/files/DZNE-2020-07724_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:141402 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2810811 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2014 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EMBO REP : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b EMBO REP : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1013012 |k AG Alamoudi |l Cryo-electron microscopy and tomography |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013012 |
| 980 | _ | _ | |a UNRESTRICTED |
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