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000141482 0247_ $$2doi$$a10.1136/jnnp-2019-320439
000141482 0247_ $$2pmid$$apmid:31182509
000141482 0247_ $$2ISSN$$a0022-3050
000141482 0247_ $$2ISSN$$a0266-8637
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000141482 0247_ $$2ISSN$$a1468-330X
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000141482 0247_ $$2ISSN$$a2753-0485
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000141482 041__ $$aEnglish
000141482 082__ $$a610
000141482 1001_ $$aGazzina, Stefano$$b0
000141482 245__ $$aEducation modulates brain maintenance in presymptomatic frontotemporal dementia.
000141482 260__ $$aLondon$$bBMJ Publishing Group$$c2019
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000141482 520__ $$aCognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time.Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling.Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers.This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.
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000141482 650_2 $$2MeSH$$aAdult
000141482 650_2 $$2MeSH$$aAsymptomatic Diseases
000141482 650_2 $$2MeSH$$aBrain: diagnostic imaging
000141482 650_2 $$2MeSH$$aBrain: pathology
000141482 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000141482 650_2 $$2MeSH$$aCerebrospinal Fluid: diagnostic imaging
000141482 650_2 $$2MeSH$$aEducational Status
000141482 650_2 $$2MeSH$$aFemale
000141482 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnostic imaging
000141482 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000141482 650_2 $$2MeSH$$aFrontotemporal Dementia: psychology
000141482 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000141482 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000141482 650_2 $$2MeSH$$aGray Matter: pathology
000141482 650_2 $$2MeSH$$aHumans
000141482 650_2 $$2MeSH$$aMale
000141482 650_2 $$2MeSH$$aMental Status and Dementia Tests
000141482 650_2 $$2MeSH$$aMiddle Aged
000141482 650_2 $$2MeSH$$aOrgan Size
000141482 650_2 $$2MeSH$$aPrincipal Component Analysis
000141482 650_2 $$2MeSH$$aProgranulins: genetics
000141482 650_2 $$2MeSH$$aWhite Matter: diagnostic imaging
000141482 650_2 $$2MeSH$$aWhite Matter: pathology
000141482 650_2 $$2MeSH$$atau Proteins: genetics
000141482 7001_ $$aGrassi, Mario$$b1
000141482 7001_ $$aPremi, Enrico$$b2
000141482 7001_ $$aCosseddu, Maura$$b3
000141482 7001_ $$aAlberici, Antonella$$b4
000141482 7001_ $$aArchetti, Silvana$$b5
000141482 7001_ $$aGasparotti, Roberto$$b6
000141482 7001_ $$aVan Swieten, John$$b7
000141482 7001_ $$aGalimberti, Daniela$$b8
000141482 7001_ $$aSanchez-Valle, Raquel$$b9
000141482 7001_ $$aLaforce, Robert Jr$$b10
000141482 7001_ $$aMoreno, Fermin$$b11
000141482 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b12$$udzne
000141482 7001_ $$aGraff, Caroline$$b13
000141482 7001_ $$aMasellis, Mario$$b14
000141482 7001_ $$aTartaglia, Maria Carmela$$b15
000141482 7001_ $$aRowe, James B$$b16
000141482 7001_ $$aVandenberghe, Rik$$b17
000141482 7001_ $$aFinger, Elizabeth$$b18
000141482 7001_ $$aTagliavini, Fabrizio$$b19
000141482 7001_ $$ade Mendonça, Alexandre$$b20
000141482 7001_ $$aSantana, Isabel$$b21
000141482 7001_ $$aButler, Christopher R$$b22
000141482 7001_ $$aDucharme, Simon$$b23
000141482 7001_ $$aGerhard, Alex$$b24
000141482 7001_ $$0P:(DE-2719)2810712$$aDanek, Adrian$$b25$$udzne
000141482 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b26$$udzne
000141482 7001_ $$aOtto, Markus$$b27
000141482 7001_ $$aFrisoni, Giovanni$$b28
000141482 7001_ $$aSorbi, Sandro$$b29
000141482 7001_ $$aPadovani, Alessandro$$b30
000141482 7001_ $$aRohrer, Jonathan D$$b31
000141482 7001_ $$0P:(DE-HGF)0$$aBorroni, Barbara$$b32$$eCorresponding author
000141482 7001_ $$aGenetic FTD Initiative, GENFI$$b33
000141482 7001_ $$aAlmeida, Maria Rosario$$b34
000141482 7001_ $$aAnderl-Straub, Sarah$$b35
000141482 7001_ $$aAndersson, Christin$$b36
000141482 7001_ $$aAntonell, Anna$$b37
000141482 7001_ $$aArighi, Andrea$$b38
000141482 7001_ $$aBalasa, Mircea$$b39
000141482 7001_ $$aBarandiaran, Myriam$$b40
000141482 7001_ $$aBargalló, Nuria$$b41
000141482 7001_ $$aBartha, Robart$$b42
000141482 7001_ $$aBender, Benjamin$$b43
000141482 7001_ $$aBenussi, Luisa$$b44
000141482 7001_ $$aBinetti, Giuliano$$b45
000141482 7001_ $$aBlack, Sandra$$b46
000141482 7001_ $$aBocchetta, Martina$$b47
000141482 7001_ $$aBorrego-Ecija, Sergi$$b48
000141482 7001_ $$aBras, Jose$$b49
000141482 7001_ $$aBruffaerts, Rose$$b50
000141482 7001_ $$aCaroppo, Paola$$b51
000141482 7001_ $$aCash, David$$b52
000141482 7001_ $$aCastelo-Branco, Miguel$$b53
000141482 7001_ $$aConvery, Rhian$$b54
000141482 7001_ $$aCope, Thomas$$b55
000141482 7001_ $$aArriba, María de$$b56
000141482 7001_ $$aDi Fede, Giuseppe$$b57
000141482 7001_ $$aDíaz, Zigor$$b58
000141482 7001_ $$aDick, Katrina M$$b59
000141482 7001_ $$aDuro, Diana$$b60
000141482 7001_ $$aFerreira, Carlos$$b61
000141482 7001_ $$aFerreira, Catarina B$$b62
000141482 7001_ $$aFlanagan, Toby$$b63
000141482 7001_ $$aFox, Nick$$b64
000141482 7001_ $$aFreedman, Morris$$b65
000141482 7001_ $$aFumagalli, Giorgio$$b66
000141482 7001_ $$aGabilondo, Alazne$$b67
000141482 7001_ $$aGauthier, Serge$$b68
000141482 7001_ $$aGhidoni, Roberta$$b69
000141482 7001_ $$aGiaccone, Giorgio$$b70
000141482 7001_ $$aGorostidi, Ana$$b71
000141482 7001_ $$aGreaves, Caroline$$b72
000141482 7001_ $$aGuerreiro, Rita$$b73
000141482 7001_ $$aHeller, Carolin$$b74
000141482 7001_ $$aHoegen, Tobias$$b75
000141482 7001_ $$aIndakoetxea, Begoña$$b76
000141482 7001_ $$aJelic, Vesna$$b77
000141482 7001_ $$aJiskoot, Lize$$b78
000141482 7001_ $$0P:(DE-HGF)0$$aKarnath, Hans-Otto$$b79
000141482 7001_ $$aKeren, Ron$$b80
000141482 7001_ $$aLeitão, Maria João$$b81
000141482 7001_ $$aLladó, Albert$$b82
000141482 7001_ $$aLombardi, Gemma$$b83
000141482 7001_ $$aLoosli, Sandra$$b84
000141482 7001_ $$aMaruta, Carolina$$b85
000141482 7001_ $$aMead, Simon$$b86
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000141482 7001_ $$aMiltenberger, Gabriel$$b88
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000141482 7001_ $$aPijnenburg, Yolande$$b100
000141482 7001_ $$aPrioni, Sara$$b101
000141482 7001_ $$aPrix, Catharina$$b102
000141482 7001_ $$aRademakers, Rosa$$b103
000141482 7001_ $$aRedaelli, Veronica$$b104
000141482 7001_ $$aRittman, Tim$$b105
000141482 7001_ $$aRogaeva, Ekaterina$$b106
000141482 7001_ $$aRosa-Neto, Pedro$$b107
000141482 7001_ $$aRossi, Giacomina$$b108
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000141482 7001_ $$aShoesmith, Christen$$b114
000141482 7001_ $$aTábuas-Pereira, Miguel$$b115
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000141482 7001_ $$aTang-Wai, David$$b117
000141482 7001_ $$aThomas, David L$$b118
000141482 7001_ $$aThonberg, Hakan$$b119
000141482 7001_ $$aTimberlake, Carolyn$$b120
000141482 7001_ $$aTiraboschi, Pietro$$b121
000141482 7001_ $$aVandamme, Philip$$b122
000141482 7001_ $$aVandenbulcke, Mathieu$$b123
000141482 7001_ $$aVeldsman, Michele$$b124
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000141482 7001_ $$0P:(DE-HGF)0$$aWilke, Carlo$$b127
000141482 7001_ $$aZetterberg, Henrik$$b128
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