Journal Article

DZNE-2020-07806

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Education modulates brain maintenance in presymptomatic frontotemporal dementia.

Gazzina, S. ; Grassi, M. ; Premi, E. ; Cosseddu, M. ; Alberici, A. ; Archetti, S. ; Gasparotti, R. ; Van Swieten, J. ; Galimberti, D. ; Sanchez-Valle, R. ; Laforce, R. J. ; Moreno, F. ; Synofzik, M.DZNE* ; Graff, C. ; Masellis, M. ; Tartaglia, M. C. ; Rowe, J. B. ; Vandenberghe, R. ; Finger, E. ; Tagliavini, F. ; de Mendonça, A. ; Santana, I. ; Butler, C. R. ; Ducharme, S. ; Gerhard, A. ; Danek, A.DZNE* ; Levin, J.DZNE* ; Otto, M. ; Frisoni, G. ; Sorbi, S. ; Padovani, A. ; Rohrer, J. D. ; Borroni, B. (Corresponding author) ; Genetic FTD Initiative, G. ; Almeida, M. R. ; Anderl-Straub, S. ; Andersson, C. ; Antonell, A. ; Arighi, A. ; Balasa, M. ; Barandiaran, M. ; Bargalló, N. ; Bartha, R. ; Bender, B. ; Benussi, L. ; Binetti, G. ; Black, S. ; Bocchetta, M. ; Borrego-Ecija, S. ; Bras, J. ; Bruffaerts, R. ; Caroppo, P. ; Cash, D. ; Castelo-Branco, M. ; Convery, R. ; Cope, T. ; Arriba, M. d. ; Di Fede, G. ; Díaz, Z. ; Dick, K. M. ; Duro, D. ; Ferreira, C. ; Ferreira, C. B. ; Flanagan, T. ; Fox, N. ; Freedman, M. ; Fumagalli, G. ; Gabilondo, A. ; Gauthier, S. ; Ghidoni, R. ; Giaccone, G. ; Gorostidi, A. ; Greaves, C. ; Guerreiro, R. ; Heller, C. ; Hoegen, T. ; Indakoetxea, B. ; Jelic, V. ; Jiskoot, L. ; Karnath, H.-O. ; Keren, R. ; Leitão, M. J. ; Lladó, A. ; Lombardi, G. ; Loosli, S. ; Maruta, C. ; Mead, S. ; Meeter, L. ; Miltenberger, G. ; Minkelen, R. v. ; Mitchell, S. ; Nacmias, B. ; Neason, M. ; Nicholas, J. ; Öijerstedt, L. ; Olives, J. ; Panman, J. ; Papma, J. ; Patzig, M. ; Pievani, M. ; Pijnenburg, Y. ; Prioni, S. ; Prix, C. ; Rademakers, R. ; Redaelli, V. ; Rittman, T. ; Rogaeva, E. ; Rosa-Neto, P. ; Rossi, G. ; Rossor, M. ; Santiago, B. ; Scarpini, E. ; Semler, E. ; Shafei, R. ; Shoesmith, C. ; Tábuas-Pereira, M. ; Tainta, M. ; Tang-Wai, D. ; Thomas, D. L. ; Thonberg, H. ; Timberlake, C. ; Tiraboschi, P. ; Vandamme, P. ; Vandenbulcke, M. ; Veldsman, M. ; Verdelho, A. ; Villanua, J. ; Wilke, C. ; Zetterberg, H. ; Zulaica, M.

2019
BMJ Publishing Group London

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Please use a persistent id in citations: doi:10.1136/jnnp-2019-320439

Abstract: Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time.Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling.Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers.This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

Keyword(s): Adult (MeSH) ; Asymptomatic Diseases (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: pathology (MeSH) ; C9orf72 Protein: genetics (MeSH) ; Cerebrospinal Fluid: diagnostic imaging (MeSH) ; Educational Status (MeSH) ; Female (MeSH) ; Frontotemporal Dementia: diagnostic imaging (MeSH) ; Frontotemporal Dementia: genetics (MeSH) ; Frontotemporal Dementia: psychology (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Gray Matter: pathology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Mental Status and Dementia Tests (MeSH) ; Middle Aged (MeSH) ; Organ Size (MeSH) ; Principal Component Analysis (MeSH) ; Progranulins: genetics (MeSH) ; White Matter: diagnostic imaging (MeSH) ; White Matter: pathology (MeSH) ; tau Proteins: genetics (MeSH)

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser 1)
2. U Clinical Researchers - München (U Clinical Researchers - München)
3. Clinical Dementia Research München (Clinical Dementia Research München)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; National-Konsortium ; SCOPUS ; Web of Science Core Collection

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