TY  - JOUR
AU  - Gazzina, Stefano
AU  - Grassi, Mario
AU  - Premi, Enrico
AU  - Cosseddu, Maura
AU  - Alberici, Antonella
AU  - Archetti, Silvana
AU  - Gasparotti, Roberto
AU  - Van Swieten, John
AU  - Galimberti, Daniela
AU  - Sanchez-Valle, Raquel
AU  - Laforce, Robert Jr
AU  - Moreno, Fermin
AU  - Synofzik, Matthis
AU  - Graff, Caroline
AU  - Masellis, Mario
AU  - Tartaglia, Maria Carmela
AU  - Rowe, James B
AU  - Vandenberghe, Rik
AU  - Finger, Elizabeth
AU  - Tagliavini, Fabrizio
AU  - de Mendonça, Alexandre
AU  - Santana, Isabel
AU  - Butler, Christopher R
AU  - Ducharme, Simon
AU  - Gerhard, Alex
AU  - Danek, Adrian
AU  - Levin, Johannes
AU  - Otto, Markus
AU  - Frisoni, Giovanni
AU  - Sorbi, Sandro
AU  - Padovani, Alessandro
AU  - Rohrer, Jonathan D
AU  - Borroni, Barbara
AU  - Genetic FTD Initiative, GENFI
AU  - Almeida, Maria Rosario
AU  - Anderl-Straub, Sarah
AU  - Andersson, Christin
AU  - Antonell, Anna
AU  - Arighi, Andrea
AU  - Balasa, Mircea
AU  - Barandiaran, Myriam
AU  - Bargalló, Nuria
AU  - Bartha, Robart
AU  - Bender, Benjamin
AU  - Benussi, Luisa
AU  - Binetti, Giuliano
AU  - Black, Sandra
AU  - Bocchetta, Martina
AU  - Borrego-Ecija, Sergi
AU  - Bras, Jose
AU  - Bruffaerts, Rose
AU  - Caroppo, Paola
AU  - Cash, David
AU  - Castelo-Branco, Miguel
AU  - Convery, Rhian
AU  - Cope, Thomas
AU  - Arriba, María de
AU  - Di Fede, Giuseppe
AU  - Díaz, Zigor
AU  - Dick, Katrina M
AU  - Duro, Diana
AU  - Ferreira, Carlos
AU  - Ferreira, Catarina B
AU  - Flanagan, Toby
AU  - Fox, Nick
AU  - Freedman, Morris
AU  - Fumagalli, Giorgio
AU  - Gabilondo, Alazne
AU  - Gauthier, Serge
AU  - Ghidoni, Roberta
AU  - Giaccone, Giorgio
AU  - Gorostidi, Ana
AU  - Greaves, Caroline
AU  - Guerreiro, Rita
AU  - Heller, Carolin
AU  - Hoegen, Tobias
AU  - Indakoetxea, Begoña
AU  - Jelic, Vesna
AU  - Jiskoot, Lize
AU  - Karnath, Hans-Otto
AU  - Keren, Ron
AU  - Leitão, Maria João
AU  - Lladó, Albert
AU  - Lombardi, Gemma
AU  - Loosli, Sandra
AU  - Maruta, Carolina
AU  - Mead, Simon
AU  - Meeter, Lieke
AU  - Miltenberger, Gabriel
AU  - Minkelen, Rick van
AU  - Mitchell, Sara
AU  - Nacmias, Benedetta
AU  - Neason, Mollie
AU  - Nicholas, Jennifer
AU  - Öijerstedt, Linn
AU  - Olives, Jaume
AU  - Panman, Jessica
AU  - Papma, Janne
AU  - Patzig, Maximilian
AU  - Pievani, Michela
AU  - Pijnenburg, Yolande
AU  - Prioni, Sara
AU  - Prix, Catharina
AU  - Rademakers, Rosa
AU  - Redaelli, Veronica
AU  - Rittman, Tim
AU  - Rogaeva, Ekaterina
AU  - Rosa-Neto, Pedro
AU  - Rossi, Giacomina
AU  - Rossor, Martin
AU  - Santiago, Beatriz
AU  - Scarpini, Elio
AU  - Semler, Elisa
AU  - Shafei, Rachelle
AU  - Shoesmith, Christen
AU  - Tábuas-Pereira, Miguel
AU  - Tainta, Mikel
AU  - Tang-Wai, David
AU  - Thomas, David L
AU  - Thonberg, Hakan
AU  - Timberlake, Carolyn
AU  - Tiraboschi, Pietro
AU  - Vandamme, Philip
AU  - Vandenbulcke, Mathieu
AU  - Veldsman, Michele
AU  - Verdelho, Ana
AU  - Villanua, Jorge
AU  - Wilke, Carlo
AU  - Zetterberg, Henrik
AU  - Zulaica, Miren
TI  - Education modulates brain maintenance in presymptomatic frontotemporal dementia.
JO  - Journal of neurology, neurosurgery, and psychiatry
VL  - 90
IS  - 10
SN  - 0022-3050
CY  - London
PB  - BMJ Publishing Group
M1  - DZNE-2020-07806
SP  - 1124-1130
PY  - 2019
AB  - Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time.Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling.Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers.This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.
KW  - Adult
KW  - Asymptomatic Diseases
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - C9orf72 Protein: genetics
KW  - Cerebrospinal Fluid: diagnostic imaging
KW  - Educational Status
KW  - Female
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: psychology
KW  - Genetic Predisposition to Disease
KW  - Gray Matter: diagnostic imaging
KW  - Gray Matter: pathology
KW  - Humans
KW  - Male
KW  - Mental Status and Dementia Tests
KW  - Middle Aged
KW  - Organ Size
KW  - Principal Component Analysis
KW  - Progranulins: genetics
KW  - White Matter: diagnostic imaging
KW  - White Matter: pathology
KW  - tau Proteins: genetics
LB  - PUB:(DE-HGF)16
C6  - pmid:31182509
DO  - DOI:10.1136/jnnp-2019-320439
UR  - https://pub.dzne.de/record/141482
ER  -