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@ARTICLE{Gazzina:141482,
author = {Gazzina, Stefano and Grassi, Mario and Premi, Enrico and
Cosseddu, Maura and Alberici, Antonella and Archetti,
Silvana and Gasparotti, Roberto and Van Swieten, John and
Galimberti, Daniela and Sanchez-Valle, Raquel and Laforce,
Robert Jr and Moreno, Fermin and Synofzik, Matthis and
Graff, Caroline and Masellis, Mario and Tartaglia, Maria
Carmela and Rowe, James B and Vandenberghe, Rik and Finger,
Elizabeth and Tagliavini, Fabrizio and de Mendonça,
Alexandre and Santana, Isabel and Butler, Christopher R and
Ducharme, Simon and Gerhard, Alex and Danek, Adrian and
Levin, Johannes and Otto, Markus and Frisoni, Giovanni and
Sorbi, Sandro and Padovani, Alessandro and Rohrer, Jonathan
D and Borroni, Barbara and Genetic FTD Initiative, GENFI and
Almeida, Maria Rosario and Anderl-Straub, Sarah and
Andersson, Christin and Antonell, Anna and Arighi, Andrea
and Balasa, Mircea and Barandiaran, Myriam and Bargalló,
Nuria and Bartha, Robart and Bender, Benjamin and Benussi,
Luisa and Binetti, Giuliano and Black, Sandra and Bocchetta,
Martina and Borrego-Ecija, Sergi and Bras, Jose and
Bruffaerts, Rose and Caroppo, Paola and Cash, David and
Castelo-Branco, Miguel and Convery, Rhian and Cope, Thomas
and Arriba, María de and Di Fede, Giuseppe and Díaz, Zigor
and Dick, Katrina M and Duro, Diana and Ferreira, Carlos and
Ferreira, Catarina B and Flanagan, Toby and Fox, Nick and
Freedman, Morris and Fumagalli, Giorgio and Gabilondo,
Alazne and Gauthier, Serge and Ghidoni, Roberta and
Giaccone, Giorgio and Gorostidi, Ana and Greaves, Caroline
and Guerreiro, Rita and Heller, Carolin and Hoegen, Tobias
and Indakoetxea, Begoña and Jelic, Vesna and Jiskoot, Lize
and Karnath, Hans-Otto and Keren, Ron and Leitão, Maria
João and Lladó, Albert and Lombardi, Gemma and Loosli,
Sandra and Maruta, Carolina and Mead, Simon and Meeter,
Lieke and Miltenberger, Gabriel and Minkelen, Rick van and
Mitchell, Sara and Nacmias, Benedetta and Neason, Mollie and
Nicholas, Jennifer and Öijerstedt, Linn and Olives, Jaume
and Panman, Jessica and Papma, Janne and Patzig, Maximilian
and Pievani, Michela and Pijnenburg, Yolande and Prioni,
Sara and Prix, Catharina and Rademakers, Rosa and Redaelli,
Veronica and Rittman, Tim and Rogaeva, Ekaterina and
Rosa-Neto, Pedro and Rossi, Giacomina and Rossor, Martin and
Santiago, Beatriz and Scarpini, Elio and Semler, Elisa and
Shafei, Rachelle and Shoesmith, Christen and
Tábuas-Pereira, Miguel and Tainta, Mikel and Tang-Wai,
David and Thomas, David L and Thonberg, Hakan and
Timberlake, Carolyn and Tiraboschi, Pietro and Vandamme,
Philip and Vandenbulcke, Mathieu and Veldsman, Michele and
Verdelho, Ana and Villanua, Jorge and Wilke, Carlo and
Zetterberg, Henrik and Zulaica, Miren},
title = {{E}ducation modulates brain maintenance in presymptomatic
frontotemporal dementia.},
journal = {Journal of neurology, neurosurgery, and psychiatry},
volume = {90},
number = {10},
issn = {0022-3050},
address = {London},
publisher = {BMJ Publishing Group},
reportid = {DZNE-2020-07806},
pages = {1124-1130},
year = {2019},
abstract = {Cognitively engaging lifestyles have been associated with
reduced risk of conversion to dementia. Multiple mechanisms
have been advocated, including increased brain volumes (ie,
brain reserve) and reduced disease progression (ie, brain
maintenance). In cross-sectional studies of presymptomatic
frontotemporal dementia (FTD), higher education has been
related to increased grey matter volume. Here, we examine
the effect of education on grey matter loss over
time.Two-hundred twenty-nine subjects at-risk of carrying a
pathogenic mutation leading to FTD underwent longitudinal
cognitive assessment and T1-weighted MRI at baseline and at
1 year follow-up. The first principal component score of the
graph-Laplacian Principal Component Analysis on 112 grey
matter region-of-interest volumes was used to summarise the
grey matter volume (GMV). The effects of education on
cognitive performances and GMV at baseline and on the change
between 1 year follow-up and baseline (slope) were tested by
Structural Equation Modelling.Highly educated at-risk
subjects had better cognition and higher grey matter volume
at baseline; moreover, higher educational attainment was
associated with slower loss of grey matter over time in
mutation carriers.This longitudinal study demonstrates that
even in presence of ongoing pathological processes,
education may facilitate both brain reserve and brain
maintenance in the presymptomatic phase of genetic FTD.},
keywords = {Adult / Asymptomatic Diseases / Brain: diagnostic imaging /
Brain: pathology / C9orf72 Protein: genetics / Cerebrospinal
Fluid: diagnostic imaging / Educational Status / Female /
Frontotemporal Dementia: diagnostic imaging / Frontotemporal
Dementia: genetics / Frontotemporal Dementia: psychology /
Genetic Predisposition to Disease / Gray Matter: diagnostic
imaging / Gray Matter: pathology / Humans / Male / Mental
Status and Dementia Tests / Middle Aged / Organ Size /
Principal Component Analysis / Progranulins: genetics /
White Matter: diagnostic imaging / White Matter: pathology /
tau Proteins: genetics},
cin = {AG Gasser 1 / U Clinical Researchers - München / Clinical
Dementia Research München},
ddc = {610},
cid = {I:(DE-2719)1210000 / I:(DE-2719)7000003 /
I:(DE-2719)1111016},
pnm = {345 - Population Studies and Genetics (POF3-345) / 344 -
Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-345 / G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31182509},
doi = {10.1136/jnnp-2019-320439},
url = {https://pub.dzne.de/record/141482},
}
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