Journal Article (Review Article)

DZNE-2020-07897

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Microglia Biology: One Century of Evolving Concepts.

Prinz, M. (Corresponding author) ; Jung, S. ; Priller, J. (Last author)DZNE*

2019
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cell.2019.08.053

Abstract: Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better defined. Although many questions about microglia and their roles in human diseases remain unanswered, the prospect of targeting microglia for the treatment of neurological and psychiatric disorders is tantalizing.

Keyword(s): Animals (MeSH) ; Homeostasis (MeSH) ; Humans (MeSH) ; Microglia: cytology (MeSH) ; Microglia: metabolism (MeSH) ; Microglia: physiology (MeSH) ; Neurodegenerative Diseases: etiology (MeSH) ; Neurogenesis (MeSH) ; Transcriptome (MeSH)

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Contributing Institute(s):

1. Translational Neuropsychiatry (AG Priller)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 60 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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