Journal Article

DZNE-2020-07911

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Network-Specific Synchronization of Electrical Slow-Wave Oscillations Regulates Sleep Drive in Drosophila.

Raccuglia, D. ; Huang, S. ; Ender, A.DZNE* ; Heim, M.-M. ; Laber, D. ; Suárez-Grimalt, R. ; Liotta, A. ; Sigrist, S. J. ; Geiger, J. R. P. ; Owald, D. (Corresponding author)

2019
Current Biology Ltd. London

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Please use a persistent id in citations: doi:10.1016/j.cub.2019.08.070

Abstract: Slow-wave rhythms characteristic of deep sleep oscillate in the delta band (0.5-4 Hz) and can be found across various brain regions in vertebrates. Across phyla, however, an understanding of the mechanisms underlying oscillations and how these link to behavior remains limited. Here, we discover compound delta oscillations in the sleep-regulating R5 network of Drosophila. We find that the power of these slow-wave oscillations increases with sleep need and is subject to diurnal variation. Optical multi-unit voltage recordings reveal that single R5 neurons get synchronized by activating circadian input pathways. We show that this synchronization depends on NMDA receptor (NMDAR) coincidence detector function, and that an interplay of cholinergic and glutamatergic inputs regulates oscillatory frequency. Genetically targeting the coincidence detector function of NMDARs in R5, and thus the uncovered mechanism underlying synchronization, abolished network-specific compound slow-wave oscillations. It also disrupted sleep and facilitated light-induced wakening, establishing a role for slow-wave oscillations in regulating sleep and sensory gating. We therefore propose that the synchronization-based increase in oscillatory power likely represents an evolutionarily conserved, potentially 'optimal,' strategy for constructing sleep-regulating sensory gates.

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Contributing Institute(s):

1. Aging of synapse structure and function (AG Sigrist)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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