Journal Article

DZNE-2020-07957

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mapping microglia states in the human brain through the integration of high-dimensional techniques.

Sankowski, R. ; Böttcher, C. ; Masuda, T. ; Geirsdottir, L. ; Sagar ; Sindram, E. ; Seredenina, T. ; Muhs, A. ; Scheiwe, C. ; Shah, M. J. ; Heiland, D. H. ; Schnell, O. ; Grün, D. ; Priller, J.DZNE* ; Prinz, M. (Corresponding author)

2019
Nature Publ. Group62203 London

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Please use a persistent id in citations: doi:10.1038/s41593-019-0532-y

Abstract: Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses and contribute to several neurological and psychiatric diseases. Little is known about human microglia and how they orchestrate their highly plastic, context-specific adaptive responses during pathology. Here we combined two high-dimensional technologies, single-cell RNA-sequencing and time-of-flight mass cytometry, to identify microglia states in the human brain during homeostasis and disease. This approach enabled us to identify and characterize a previously unappreciated spectrum of transcriptional states in human microglia. These transcriptional states are determined by their spatial distribution, and they further change with aging and brain tumor pathology. This description of multiple microglia phenotypes in the human CNS may open promising new avenues for subset-specific therapeutic interventions.

Keyword(s): Adolescent (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Aging: metabolism (MeSH) ; Brain: metabolism (MeSH) ; Female (MeSH) ; Flow Cytometry (MeSH) ; Glioblastoma: metabolism (MeSH) ; Humans (MeSH) ; Immunohistochemistry (MeSH) ; Male (MeSH) ; Microglia: metabolism (MeSH) ; Middle Aged (MeSH) ; Sequence Analysis, RNA (MeSH) ; Transcription, Genetic (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Clinical Study Team Berlin Priller (Clinical Study Team Berlin 1)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Sankowski, R. ; Böttcher, C.Extern* ; Masuda, T. ; Geirsdottir, L. ; Sagar ; Sindram, E. ; Seredenina, T. ; Muhs, A. ; Scheiwe, C. ; Shah, M. J. ; Heiland, D. H. ; Schnell, O. ; Grün, D. ; Priller, J. (Last author)DZNE* ; Prinz, M.
Author Correction: Mapping microglia states in the human brain through the integration of high-dimensional techniques.
Nature neuroscience 25(7), 975 (2022) [10.1038/s41593-022-01089-3]2022 BibTeX | EndNote: XML, Text | RIS

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