TY  - JOUR
AU  - Fischer, A.
AU  - Schneider, A.
AU  - Wüllner, U.
TI  - Epigenetik – neue Erkenntnisse zum Verständnis neurodegenerativer Erkrankungen  -  Epigenetic Mechanisms in Neurodegenerative Diseases
JO  - Aktuelle Neurologie
VL  - 42
IS  - 07
SN  - 0302-4350
CY  - Stuttgart
PB  - Thieme
M1  - DZNE-2020-00195
SP  - 393-401
PY  - 2015
AB  - Epigenetics describes the various structures and functions of the DNA-protein matrix (chromatin), which regulate gene expression beyond the DNA sequence. The epigenome determines the differences in the development of genetically identical cells and individuals (mono-zygotic twins). Epigenetic features such as direct biochemical modifications of DNA (methylation) are affected by environmental conditions (famine, early life stress) and are inherited in a modified form, without alteration of the DNA sequence. The analysis of epigenetic processes, in particular DNA methylation, modifications of the DNA-binding proteins, and the functions of the non-coding microRNA, opens an unexpectedly complex field of environment-gene interactions that affect the individual patterns of disease symptoms as well as effects and side effects of many drugs.The study of the epigenome hold the promise of new diagnostic and possibly therapeutic perspectives also for the two most common neurodegenerative diseases, namely Alzheimerʼs and Parkinsonʼs disease.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1055/s-0035-1552630
UR  - https://pub.dzne.de/record/144745
ER  -