Journal Article

DZNE-2020-00195

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Epigenetik – neue Erkenntnisse zum Verständnis neurodegenerativer Erkrankungen | Epigenetic Mechanisms in Neurodegenerative Diseases

Fischer, A. (First author)DZNE* ; Schneider, A.DZNE* ; Wüllner, U. (Last author)DZNE*

2015
Thieme Stuttgart

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Please use a persistent id in citations: doi:10.1055/s-0035-1552630

Abstract: Epigenetics describes the various structures and functions of the DNA-protein matrix (chromatin), which regulate gene expression beyond the DNA sequence. The epigenome determines the differences in the development of genetically identical cells and individuals (mono-zygotic twins). Epigenetic features such as direct biochemical modifications of DNA (methylation) are affected by environmental conditions (famine, early life stress) and are inherited in a modified form, without alteration of the DNA sequence. The analysis of epigenetic processes, in particular DNA methylation, modifications of the DNA-binding proteins, and the functions of the non-coding microRNA, opens an unexpectedly complex field of environment-gene interactions that affect the individual patterns of disease symptoms as well as effects and side effects of many drugs.The study of the epigenome hold the promise of new diagnostic and possibly therapeutic perspectives also for the two most common neurodegenerative diseases, namely Alzheimerʼs and Parkinsonʼs disease.

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Contributing Institute(s):

1. Biomarker Parkinson's Disease (AG Wüllner)
2. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer ; AG Fischer)
3. Translational Dementia Research Göttingen (AG Schneider Göttingen)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2015

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Database coverage:
Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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