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| Home > Publications Database > Control of hippocampal function by the medial septum |
| Dissertation / PhD Thesis | DZNE-2020-00220 |
2017
Bonn
Abstract: Locomotion is a fundamental behavior of all animals and enables specific environmental performances. Goal-oriented locomotion and navigational decisions are based on memory. Shortly before the onset of locomotion the memory system in the brain of humans and animals enters an activity-state that is specialized for the processing of spatially related input. These inputs are integrated by hippocampal neurons and underlie the formation of a precise map of the environment. During locomotion rapid association of spatial and contextual information is necessary for memory-guided navigation and spatial memories. Although hippocampal oscillations and the firing rates of hippocampal neurons are known to increase during locomotion and correlate to the velocity of locomotion, the mechanisms and neuronal circuits linking locomotor activity to speed-adapted oscillations and speed-adapted firing rates remain unresolved. With the present study I provided novel evidence for a role of medial septal glutamatergic (VGluT2+) neurons linking the generation of movementassociated hippocampal theta oscillations and the modulation of hippocampal population activity to locomotion. I show that medial septal VGluT2+ neurons are activated before locomotion onset, control the initiation and velocity of locomotion and entrain hippocampal theta rhythms. Furthermore, via septohippocampal projections onto Alveus/Oriens interneurons, this circuit modulates the activity of CA 1 pyramidal neurons in a speed-dependent manner.
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