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@ARTICLE{Maa:145124,
      author       = {Maaß, Sarah C and Riemer, Martin and Wolbers, Thomas and
                      van Rijn, Hedderik},
      title        = {{T}iming deficiencies in amnestic {M}ild {C}ognitive
                      {I}mpairment: {D}isentangling clock and memory processes.},
      journal      = {Behavioural brain research},
      volume       = {373},
      issn         = {0166-4328},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-00483},
      pages        = {112110},
      year         = {2019},
      abstract     = {Interval timing performance in cognitive decline is
                      typically characterized by decreased accuracy, precision, or
                      both. One explanation for this decreased performance is a
                      larger clock time variability. However, memory deficiencies
                      associated with cognitive decline might also affect temporal
                      performance in two alternative ways: First, memory
                      deficiencies could lead to reduced encoding of just
                      perceived durations, and thus a stronger reliance on the
                      memory traces of previous experiences (the 'prior'),
                      yielding less precise reproductions of the most current
                      experiences. Second, memory deficiencies could hamper the
                      storage of perceived intervals, thus resulting in less
                      influence of the prior. Here, we present data of 15 patients
                      with amnestic Mild Cognitive Impairment (aMCI) and 44
                      healthy, aged controls, the latter split in two groups based
                      on memory performance. All participants were tested on a
                      temporal production task to assess clock time variability
                      and a multi-duration reproduction task to assess the
                      influence of memory traces reflecting current and previous
                      experiences. Patients with aMCI showed the strongest
                      regression towards the mean in a multi-duration reproduction
                      task, followed by low-performing healthy controls and
                      high-performing healthy controls, respectively. As no
                      difference was observed between the groups in terms of clock
                      time variability, and clock variability did not
                      statistically contribute to the observed regression, this
                      increased central tendency effect was not attributable to
                      clock noise. We therefore, in line with the first
                      explanation, conclude that memory deficiencies result in a
                      stronger (relative) reliance on the prior.},
      keywords     = {Aged / Aged, 80 and over / Amnesia: psychology / Cognition:
                      physiology / Cognitive Dysfunction: physiopathology /
                      Cognitive Dysfunction: psychology / Female / Humans / Male /
                      Memory: physiology / Middle Aged / Neuropsychological Tests
                      / Reaction Time: physiology / Time Perception: physiology},
      cin          = {AG Düzel / AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31340173},
      doi          = {10.1016/j.bbr.2019.112110},
      url          = {https://pub.dzne.de/record/145124},
}