000145740 001__ 145740
000145740 005__ 20200925154157.0
000145740 037__ $$aDZNE-2020-01025
000145740 041__ $$aEnglish
000145740 1001_ $$0P:(DE-2719)2811989$$aDansokho, Dialy Cira$$b0$$eFirst author$$udzne
000145740 1112_ $$a47th Annual Meeting of the German Society for Immunology$$cErlangen$$d2017-09-12 - 2017-09-15$$wGermany
000145740 245__ $$aGeneration and characterization of patient-derived microglia-like cells for studying neuroinflammation in Alzheimer"s disease
000145740 260__ $$c2017
000145740 3367_ $$0PUB:(DE-HGF)1$$2PUB:(DE-HGF)$$aAbstract$$babstract$$mabstract$$s1598434601_4498
000145740 3367_ $$033$$2EndNote$$aConference Paper
000145740 3367_ $$2BibTeX$$aINPROCEEDINGS
000145740 3367_ $$2DRIVER$$aconferenceObject
000145740 3367_ $$2DataCite$$aOutput Types/Conference Abstract
000145740 3367_ $$2ORCID$$aOTHER
000145740 520__ $$aAlzheimer's  disease  (AD),  the  most  common  neurodegenerative  disease,  is  characterized  by  extracellular deposits of amyloid peptides (Aβ), within senile plaques, and intracellular aggregation of hyperphosphorylated Tau protein causing neurofibrillary tangles (NFTs). AD is also defined by an extensive neuronal loss and chronic neuroinflammation mediated by microglial cells and astrocytes surrounding the lesions. Numerous preclinical and  clinical studies have pointed out the strong contribution  of  neuroinflammation, in particular  microglial  responses,  in  the  progression  of  AD. Therefore, deciphering  cellular and  molecular mechanisms  underlying  these  neuroinflammatory  processes  may  pave  the  way  to  the  identification  of  new targets and biomarkers of AD. The  generation  of  patient  neural  cells  using  induced  pluripotent  stem  cell  (iPSC)  technology  has  helped  to overcome the lack of success in modeling familial and sporadic AD. To identify new pathways involved in Alzheimer"s  disease,  we have  set up,  in  our  laboratory,  a method  to  generate  microglial  cells using  patient derived  monocytes  and  iPSCs.  The  generated  microglia-like  cells  have  been  then  characterized  for  their phenotypes and functions regarding the genetic background and upon various stimulatory conditions.
000145740 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000145740 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b1$$eLast author$$udzne
000145740 8564_ $$uhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.201770300
000145740 909CO $$ooai:pub.dzne.de:145740$$pVDB
000145740 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811989$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000145740 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000008$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000145740 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000145740 9141_ $$y2017
000145740 9201_ $$0I:(DE-2719)1011303$$kAG Heneka2$$lNeuroinflammation, Biomarker$$x0
000145740 980__ $$aabstract
000145740 980__ $$aVDB
000145740 980__ $$aI:(DE-2719)1011303
000145740 980__ $$aUNRESTRICTED