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| Home > Publications Database > Generation and characterization of patient-derived microglia-like cells for studying neuroinflammation in Alzheimer"s disease |
| Home > Publications Database > Generation and characterization of patient-derived microglia-like cells for studying neuroinflammation in Alzheimer"s disease |
| Abstract | DZNE-2020-01025 |
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2017
Abstract: Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by extracellular deposits of amyloid peptides (Aβ), within senile plaques, and intracellular aggregation of hyperphosphorylated Tau protein causing neurofibrillary tangles (NFTs). AD is also defined by an extensive neuronal loss and chronic neuroinflammation mediated by microglial cells and astrocytes surrounding the lesions. Numerous preclinical and clinical studies have pointed out the strong contribution of neuroinflammation, in particular microglial responses, in the progression of AD. Therefore, deciphering cellular and molecular mechanisms underlying these neuroinflammatory processes may pave the way to the identification of new targets and biomarkers of AD. The generation of patient neural cells using induced pluripotent stem cell (iPSC) technology has helped to overcome the lack of success in modeling familial and sporadic AD. To identify new pathways involved in Alzheimer"s disease, we have set up, in our laboratory, a method to generate microglial cells using patient derived monocytes and iPSCs. The generated microglia-like cells have been then characterized for their phenotypes and functions regarding the genetic background and upon various stimulatory conditions.
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