TY  - CONF
AU  - Dansokho, Dialy Cira
AU  - Heneka, Michael
TI  - Generation and characterization of patient-derived microglia-like cells for studying neuroinflammation in Alzheimerß disease
M1  - DZNE-2020-01025
PY  - 2017
AB  - Alzheimer's  disease  (AD),  the  most  common  neurodegenerative  disease,  is  characterized  by  extracellular deposits of amyloid peptides (Aβ), within senile plaques, and intracellular aggregation of hyperphosphorylated Tau protein causing neurofibrillary tangles (NFTs). AD is also defined by an extensive neuronal loss and chronic neuroinflammation mediated by microglial cells and astrocytes surrounding the lesions. Numerous preclinical and  clinical studies have pointed out the strong contribution  of  neuroinflammation, in particular  microglial  responses,  in  the  progression  of  AD. Therefore, deciphering  cellular and  molecular mechanisms  underlying  these  neuroinflammatory  processes  may  pave  the  way  to  the  identification  of  new targets and biomarkers of AD. The  generation  of  patient  neural  cells  using  induced  pluripotent  stem  cell  (iPSC)  technology  has  helped  to overcome the lack of success in modeling familial and sporadic AD. To identify new pathways involved in Alzheimerß  disease,  we have  set up,  in  our  laboratory,  a method  to  generate  microglial  cells using  patient derived  monocytes  and  iPSCs.  The  generated  microglia-like  cells  have  been  then  characterized  for  their phenotypes and functions regarding the genetic background and upon various stimulatory conditions.
T2  - 47th Annual Meeting of the German Society for Immunology
CY  - 12 Sep 2017 - 15 Sep 2017, Erlangen (Germany)
Y2  - 12 Sep 2017 - 15 Sep 2017
M2  - Erlangen, Germany
LB  - PUB:(DE-HGF)1
UR  - https://pub.dzne.de/record/145740
ER  -