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@INPROCEEDINGS{Dansokho:145740,
      author       = {Dansokho, Dialy Cira and Heneka, Michael},
      title        = {{G}eneration and characterization of patient-derived
                      microglia-like cells for studying neuroinflammation in
                      {A}lzheimer"s disease},
      reportid     = {DZNE-2020-01025},
      year         = {2017},
      abstract     = {Alzheimer's disease (AD), the most common neurodegenerative
                      disease, is characterized by extracellular deposits of
                      amyloid peptides (Aβ), within senile plaques, and
                      intracellular aggregation of hyperphosphorylated Tau protein
                      causing neurofibrillary tangles (NFTs). AD is also defined
                      by an extensive neuronal loss and chronic neuroinflammation
                      mediated by microglial cells and astrocytes surrounding the
                      lesions. Numerous preclinical and clinical studies have
                      pointed out the strong contribution of neuroinflammation, in
                      particular microglial responses, in the progression of AD.
                      Therefore, deciphering cellular and molecular mechanisms
                      underlying these neuroinflammatory processes may pave the
                      way to the identification of new targets and biomarkers of
                      AD. The generation of patient neural cells using induced
                      pluripotent stem cell (iPSC) technology has helped to
                      overcome the lack of success in modeling familial and
                      sporadic AD. To identify new pathways involved in
                      Alzheimer"s disease, we have set up, in our laboratory, a
                      method to generate microglial cells using patient derived
                      monocytes and iPSCs. The generated microglia-like cells have
                      been then characterized for their phenotypes and functions
                      regarding the genetic background and upon various
                      stimulatory conditions.},
      month         = {Sep},
      date          = {2017-09-12},
      organization  = {47th Annual Meeting of the German
                       Society for Immunology, Erlangen
                       (Germany), 12 Sep 2017 - 15 Sep 2017},
      cin          = {AG Heneka2},
      cid          = {I:(DE-2719)1011303},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://pub.dzne.de/record/145740},
}