%0 Journal Article
%A Netea, Mihai G.
%A Domínguez-Andrés, Jorge
%A Barreiro, Luis B.
%A Chavakis, Triantafyllos
%A Divangahi, Maziar
%A Fuchs, Elaine
%A Joosten, Leo A. B.
%A van der Meer, Jos W. M.
%A Mhlanga, Musa M.
%A Mulder, Willem J. M.
%A Riksen, Niels P.
%A Schlitzer, Andreas
%A Schultze, Joachim
%A Stabell Benn, Christine
%A Sun, Joseph C.
%A Xavier, Ramnik J.
%A Latz, Eicke
%T Defining trained immunity and its role in health and disease
%J Nature reviews / Immunology
%V 20
%N 6
%@ 1474-1733
%C London
%I Nature Publ. Group
%M DZNE-2020-01051
%P 375-388
%D 2020
%X Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
%K Adaptive Immunity: genetics
%K Adaptive Immunity: immunology
%K Animals
%K Epigenesis, Genetic: immunology
%K Humans
%K Immune System: immunology
%K Immune System: metabolism
%K Immune System Diseases: genetics
%K Immune System Diseases: immunology
%K Immune Tolerance: genetics
%K Immune Tolerance: immunology
%K Immunity, Innate: genetics
%K Immunity, Innate: immunology
%K Immunologic Memory: genetics
%K Immunologic Memory: immunology
%K Inflammation: genetics
%K Inflammation: immunology
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC7186935
%$ pmid:32132681
%R 10.1038/s41577-020-0285-6
%U https://pub.dzne.de/record/151066