Journal Article (Review Article)

DZNE-2020-01051

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Defining trained immunity and its role in health and disease

Netea, M. G. (Corresponding author) ; Domínguez-Andrés, J. ; Barreiro, L. B. ; Chavakis, T. ; Divangahi, M. ; Fuchs, E. ; Joosten, L. A. B. ; van der Meer, J. W. M. ; Mhlanga, M. M. ; Mulder, W. J. M. ; Riksen, N. P. ; Schlitzer, A. ; Schultze, J.Extern* ; Stabell Benn, C. ; Sun, J. C. ; Xavier, R. J. ; Latz, E. (Last author)DZNE*

2020
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41577-020-0285-6

Abstract: Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

Keyword(s): Adaptive Immunity: genetics (MeSH) ; Adaptive Immunity: immunology (MeSH) ; Animals (MeSH) ; Epigenesis, Genetic: immunology (MeSH) ; Humans (MeSH) ; Immune System: immunology (MeSH) ; Immune System: metabolism (MeSH) ; Immune System Diseases: genetics (MeSH) ; Immune System Diseases: immunology (MeSH) ; Immune Tolerance: genetics (MeSH) ; Immune Tolerance: immunology (MeSH) ; Immunity, Innate: genetics (MeSH) ; Immunity, Innate: immunology (MeSH) ; Immunologic Memory: genetics (MeSH) ; Immunologic Memory: immunology (MeSH) ; Inflammation: genetics (MeSH) ; Inflammation: immunology (MeSH)

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz ; AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 90 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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