TY  - JOUR
AU  - Netea, Mihai G.
AU  - Domínguez-Andrés, Jorge
AU  - Barreiro, Luis B.
AU  - Chavakis, Triantafyllos
AU  - Divangahi, Maziar
AU  - Fuchs, Elaine
AU  - Joosten, Leo A. B.
AU  - van der Meer, Jos W. M.
AU  - Mhlanga, Musa M.
AU  - Mulder, Willem J. M.
AU  - Riksen, Niels P.
AU  - Schlitzer, Andreas
AU  - Schultze, Joachim
AU  - Stabell Benn, Christine
AU  - Sun, Joseph C.
AU  - Xavier, Ramnik J.
AU  - Latz, Eicke
TI  - Defining trained immunity and its role in health and disease
JO  - Nature reviews / Immunology
VL  - 20
IS  - 6
SN  - 1474-1733
CY  - London
PB  - Nature Publ. Group
M1  - DZNE-2020-01051
SP  - 375-388
PY  - 2020
AB  - Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
KW  - Adaptive Immunity: genetics
KW  - Adaptive Immunity: immunology
KW  - Animals
KW  - Epigenesis, Genetic: immunology
KW  - Humans
KW  - Immune System: immunology
KW  - Immune System: metabolism
KW  - Immune System Diseases: genetics
KW  - Immune System Diseases: immunology
KW  - Immune Tolerance: genetics
KW  - Immune Tolerance: immunology
KW  - Immunity, Innate: genetics
KW  - Immunity, Innate: immunology
KW  - Immunologic Memory: genetics
KW  - Immunologic Memory: immunology
KW  - Inflammation: genetics
KW  - Inflammation: immunology
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC7186935
C6  - pmid:32132681
DO  - DOI:10.1038/s41577-020-0285-6
UR  - https://pub.dzne.de/record/151066
ER  -