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@ARTICLE{Netea:151066,
      author       = {Netea, Mihai G. and Domínguez-Andrés, Jorge and Barreiro,
                      Luis B. and Chavakis, Triantafyllos and Divangahi, Maziar
                      and Fuchs, Elaine and Joosten, Leo A. B. and van der Meer,
                      Jos W. M. and Mhlanga, Musa M. and Mulder, Willem J. M. and
                      Riksen, Niels P. and Schlitzer, Andreas and Schultze,
                      Joachim and Stabell Benn, Christine and Sun, Joseph C. and
                      Xavier, Ramnik J. and Latz, Eicke},
      title        = {{D}efining trained immunity and its role in health and
                      disease},
      journal      = {Nature reviews / Immunology},
      volume       = {20},
      number       = {6},
      issn         = {1474-1733},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2020-01051},
      pages        = {375-388},
      year         = {2020},
      abstract     = {Immune memory is a defining feature of the acquired immune
                      system, but activation of the innate immune system can also
                      result in enhanced responsiveness to subsequent triggers.
                      This process has been termed ‘trained immunity’, a de
                      facto innate immune memory. Research in the past decade has
                      pointed to the broad benefits of trained immunity for host
                      defence but has also suggested potentially detrimental
                      outcomes in immune-mediated and chronic inflammatory
                      diseases. Here we define ‘trained immunity’ as a
                      biological process and discuss the innate stimuli and the
                      epigenetic and metabolic reprogramming events that shape the
                      induction of trained immunity.},
      subtyp        = {Review Article},
      keywords     = {Adaptive Immunity: genetics / Adaptive Immunity: immunology
                      / Animals / Epigenesis, Genetic: immunology / Humans /
                      Immune System: immunology / Immune System: metabolism /
                      Immune System Diseases: genetics / Immune System Diseases:
                      immunology / Immune Tolerance: genetics / Immune Tolerance:
                      immunology / Immunity, Innate: genetics / Immunity, Innate:
                      immunology / Immunologic Memory: genetics / Immunologic
                      Memory: immunology / Inflammation: genetics / Inflammation:
                      immunology},
      cin          = {AG Latz ; AG Latz},
      ddc          = {570},
      cid          = {I:(DE-2719)1013024},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7186935},
      pubmed       = {pmid:32132681},
      doi          = {10.1038/s41577-020-0285-6},
      url          = {https://pub.dzne.de/record/151066},
}