Home > Publications Database > Defining trained immunity and its role in health and disease > print

001     151066
005     20240510165319.0
024 7 _ |a pmc:PMC7186935
|2 pmc
024 7 _ |a 10.1038/s41577-020-0285-6
|2 doi
024 7 _ |a 1474-1733
|2 ISSN
024 7 _ |a 1474-1741
|2 ISSN
024 7 _ |a altmetric:77039563
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024 7 _ |a pmid:32132681
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037 _ _ |a DZNE-2020-01051
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Netea, Mihai G.
|0 0000-0003-2421-6052
|b 0
|e Corresponding author
245 _ _ |a Defining trained immunity and its role in health and disease
260 _ _ |a London
|c 2020
|b Nature Publ. Group
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2020-03-04
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2020-06-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
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|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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|2 EndNote
520 _ _ |a Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2020-03-04
|2 Crossref
|u http://www.springer.com/tdm
588 _ _ |a Dataset connected to CrossRef
650 _ 2 |a Adaptive Immunity: genetics
|2 MeSH
650 _ 2 |a Adaptive Immunity: immunology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Epigenesis, Genetic: immunology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Immune System: immunology
|2 MeSH
650 _ 2 |a Immune System: metabolism
|2 MeSH
650 _ 2 |a Immune System Diseases: genetics
|2 MeSH
650 _ 2 |a Immune System Diseases: immunology
|2 MeSH
650 _ 2 |a Immune Tolerance: genetics
|2 MeSH
650 _ 2 |a Immune Tolerance: immunology
|2 MeSH
650 _ 2 |a Immunity, Innate: genetics
|2 MeSH
650 _ 2 |a Immunity, Innate: immunology
|2 MeSH
650 _ 2 |a Immunologic Memory: genetics
|2 MeSH
650 _ 2 |a Immunologic Memory: immunology
|2 MeSH
650 _ 2 |a Inflammation: genetics
|2 MeSH
650 _ 2 |a Inflammation: immunology
|2 MeSH
700 1 _ |a Domínguez-Andrés, Jorge
|b 1
700 1 _ |a Barreiro, Luis B.
|b 2
700 1 _ |a Chavakis, Triantafyllos
|b 3
700 1 _ |a Divangahi, Maziar
|b 4
700 1 _ |a Fuchs, Elaine
|b 5
700 1 _ |a Joosten, Leo A. B.
|b 6
700 1 _ |a van der Meer, Jos W. M.
|b 7
700 1 _ |a Mhlanga, Musa M.
|b 8
700 1 _ |a Mulder, Willem J. M.
|b 9
700 1 _ |a Riksen, Niels P.
|b 10
700 1 _ |a Schlitzer, Andreas
|0 P:(DE-HGF)0
|b 11
700 1 _ |a Schultze, Joachim
|0 P:(DE-2719)2811660
|b 12
|u dzne
700 1 _ |a Stabell Benn, Christine
|b 13
700 1 _ |a Sun, Joseph C.
|b 14
700 1 _ |a Xavier, Ramnik J.
|b 15
700 1 _ |a Latz, Eicke
|0 P:(DE-2719)2000062
|b 16
|e Last author
773 1 8 |a 10.1038/s41577-020-0285-6
|b : Springer Science and Business Media LLC, 2020-03-04
|n 6
|p 375-388
|3 journal-article
|2 Crossref
|t Nature Reviews Immunology
|v 20
|y 2020
|x 1474-1733
773 _ _ |a 10.1038/s41577-020-0285-6
|g Vol. 20, no. 6, p. 375 - 388
|0 PERI:(DE-600)2060551-1
|n 6
|p 375-388
|t Nature reviews / Immunology
|v 20
|y 2020
|x 1474-1733
856 4 _ |u https://www.nature.com/articles/s41577-020-0285-6
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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980 _ _ |a journal
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21